Molecular structure of N-Nitroso-N-methyl-4-aminobutyric Acid, CAS Number: 61445-55-4
N-Nitroso-N-methyl-4-aminobutyric Acid (CAS 61445-55-4)
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Alternate Names:
4-(Methylnitrosoamino)butanoic Acid; N-Methyl-N-(3-carboxypropyl)nitrosamine; NMBA
Application:
N-Nitroso-N-methyl-4-aminobutyric Acid is a compound found in various tobacco types
CAS Number:
61445-55-4
Purity:
98%
Molecular Weight:
146.15
Molecular Formula:
C5H10N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Nitroso-N-methyl-4-aminobutyric acid is a chemical compound often utilized in the field of chemical research for its role as a nitrosamine. Researchers investigate the mechanisms by which nitrosamines like N-Nitroso-N-methyl-4-aminobutyric acid may cause alterations at a cellular level, particularly focusing on its interactions with biomolecules. Studies involving this chemical frequently explore its impact on DNA, where it may induce mutations due to its alkylating properties. In addition to genetic studies, N-Nitroso-N-methyl-4-aminobutyric acid is used to understand the biochemical pathways of nitrosation reactions, as its formation and stability are significant in environmental chemistry. The compound also serves as a reference substance in analytical chemistry to develop detection methods for nitrosamine contaminants in various environments.
N-Nitroso-N-methyl-4-aminobutyric Acid (CAS 61445-55-4) References
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- Nitrosamine Impurities in Angiotensin Receptor Blockers. | Shephard, EA. and Nawarskas, JJ. 2020. Cardiol Rev. 28: 262-265. PMID: 32467427
- A Cautionary Tale: Quantitative LC-HRMS Analytical Procedures for the Analysis of N-Nitrosodimethylamine in Metformin. | Yang, J., et al. 2020. AAPS J. 22: 89. PMID: 32613429
- Understanding the molecular-pharmaceutical basis of sartan recalls focusing on valsartan. | Ray, A., et al. 2020. Glob Cardiol Sci Pract. 2020: e202025. PMID: 33426042
- Analytical lifecycle management for comprehensive and universal nitrosamine analysis in various pharmaceutical formulations by supercritical fluid chromatography. | Schmidtsdorff, S., et al. 2021. J Pharm Biomed Anal. 197: 113960. PMID: 33626447
- Critical Analysis of Drug Product Recalls due to Nitrosamine Impurities. | Bharate, SS. 2021. J Med Chem. 64: 2923-2936. PMID: 33706513
- Estimated Cancer Risks Associated with Nitrosamine Contamination in Commonly Used Medications. | Li, K., et al. 2021. Int J Environ Res Public Health. 18: PMID: 34574388
- Risk assessment for nitrosated pharmaceuticals: A future perspective in drug development. | Schmidtsdorff, S., et al. 2022. Arch Pharm (Weinheim). 355: e2100435. PMID: 35088435
- A multi-analyte LC-MS/MS method for screening and quantification of nitrosamines in sartans. | Chang, SH., et al. 2020. J Food Drug Anal. 28: 292-301. PMID: 35696119
- A Multi-Analyte LC-MS/MS Method for Determination and Quantification of Six Nitrosamine Impurities in Sartans like Azilsartan, Valsartan, Telmisartan, Olmesartan, Losartan and Irbesartan. | Gopireddy, RR., et al. 2022. J Chromatogr Sci.. PMID: 35830866
- Determination of Genotoxic Impurity N-Nitroso-N-methyl-4-aminobutyric Acid in Four Sartan Substances through Using Liquid Chromatography-Tandem Mass Spectrometry. | Xie, B., et al. 2022. Molecules. 27: PMID: 36364326
- Rapid Quantitation of Four Nitrosamine Impurities in Angiotensin Receptor Blocker Drug Substances. | Zhang, J., et al. 2022. J Pharm Sci.. PMID: 36509171
- Investigation of Carcinogenic Impurities of N-Nitrosamines in Sartan Pharmaceutical Products Marketed in Brazil: Development and Validation of Method Based on High-Performance Liquid Chromatography-Tandem Mass Spectrometry. | Monteiro, MA., et al. 2023. J Pharm Sci.. PMID: 36657719
- Identification and occurrence of two new N-nitrosamino acids in tobacco products: 3-(N-nitroso-N-methylamino)propionic acid and 4-(N-nitroso-N-methylamino)butyric acid. | Ohshima, H., et al. 1985. Cancer Lett. 26: 153-62. PMID: 3978605
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Nitroso-N-methyl-4-aminobutyric Acid, 10 mg | sc-212252 | 10 mg | $410.00 | |||
N-Nitroso-N-methyl-4-aminobutyric Acid, 25 mg | sc-212252A | 25 mg | $816.00 | |||
N-Nitroso-N-methyl-4-aminobutyric Acid, 1 g | sc-212252C | 1 g | $20400.00 |