Molecular structure of N-Nitroso-N-ethylurea, CAS Number: 759-73-9
N-Nitroso-N-ethylurea (CAS 759-73-9)
Alternate Names:
1-Ethyl-1-nitrosourea; N-Ethyl-N-nitroso-urea
Application:
N-Nitroso-N-ethylurea is a precursor of Diazoethane
CAS Number:
759-73-9
Molecular Weight:
117.11
Molecular Formula:
C3H7N3O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Nitroso-N-ethylurea serves as a highly effective mutagenic agent utilized extensively in scientific research to induce mutations across various organisms. As a member of the nitrosourea compound family, N-Nitroso-N-ethylurea is renowned for its capacity to alkylate DNA and inflict DNA damage. Its significance in genetic studies stems from its ability to induce point mutations, which are single nucleotide alterations in DNA that can result in modified gene function. As a potent alkylating agent, N-Nitroso-N-ethylurea causes DNA damage by introducing an ethyl group to the O6 position of guanine. This ethylation event can disrupt the accurate pairing of DNA bases during replication, thereby resulting in point mutations.
N-Nitroso-N-ethylurea (CAS 759-73-9) References
- Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid. | Polyzos, A., et al. 2006. Mutat Res. 598: 73-84. PMID: 16516931
- N-nitroso-N-methylurea and N-nitroso-N-ethylurea induce upregulation of cellular NF-kappa B activity through protein kinase C-dependent pathway in human malignant keratinocytes. | Moon, KY. 2010. Arch Pharm Res. 33: 133-9. PMID: 20191354
- [The carcinogenic activity of N-nitroso-N-ethylurea in kidney organ cultures of mice exposed transplacentally to cobalamin coenzymes and folinic acid]. | Golenko, OD., et al. 1991. Biull Eksp Biol Med. 111: 292-4. PMID: 2054508
- N-nitroso-N-ethylurea activates DNA damage surveillance pathways and induces transformation in mammalian cells. | Bodakuntla, S., et al. 2014. BMC Cancer. 14: 287. PMID: 24758542
- [The modifying influence of adenosylcobalamin on the transplacental carcinogenic effect of N-nitroso-N-ethylurea in organ cultures of the kidneys of DBA/2 mice]. | Golenko, OD., et al. 1989. Eksp Onkol. 11: 11-4. PMID: 2752937
- Different mutational profiles induced by N-nitroso-N-ethylurea: effects of dose and error-prone DNA repair and correlations with DNA adducts. | Zielenska, M., et al. 1988. Environ Mol Mutagen. 11: 473-85. PMID: 3286248
- The induction of DNA strand breaks at specific sites by N-nitroso-N-ethylurea depends on the phases of the cell cycle. | Leitao, J., et al. 1987. Mutat Res. 180: 239-48. PMID: 3657822
- Relation between development of leukemia and duration of N-nitroso-N-ethylurea treatment in DONRYU rats. | Ogiu, T., et al. 1985. J Natl Cancer Inst. 75: 743-9. PMID: 3862906
- Changing sensitivity of neonatal rats to tumorigenic effects of N-nitroso-N-ethylurea and X-radiation, given singly or combined. | Knowles, JF. 1985. J Natl Cancer Inst. 74: 853-7. PMID: 3886991
- Evidence for a major premutagenic ethyldeoxythymidine-DNA adduct in an in vivo system: N-nitroso-N-ethylurea-treated Salmonella typhimurium. | Hu, YC. and Guttenplan, JB. 1985. Carcinogenesis. 6: 1513-6. PMID: 3899401
- Reduction of N-nitroso-N-ethylurea-induced neurogenic tumors by X-radiation: a life-span study in rats. | Knowles, JF. 1984. J Natl Cancer Inst. 72: 133-7. PMID: 6363788
- Mutagenesis and O6-ethylguanine levels in DNA from N-nitroso-N-ethylurea-treated Salmonella typhimurium: evidence for a high mutational efficiency of O6-ethylguanine. | Guttenplan, JB. 1984. Carcinogenesis. 5: 155-9. PMID: 6365347
- Genetics of transplacentally induced teratogenic and carcinogenic effects in rabbits treated with N-nitroso-N-ethylurea. | Fox, RR., et al. 1982. J Natl Cancer Inst. 69: 1411-7. PMID: 6958914
- N-nitroso-N-ethylurea-induced hamster melanoma: a new method for efficient induction and schwannian differentiation of melanoma. | Nemoto, T., et al. 1993. Jpn J Cancer Res. 84: 512-7. PMID: 8320168
- Testicular development and fertility of mice treated prenatally with N-nitroso-N-ethylurea at various gestational stages. | Nagao, T., et al. 1996. Teratog Carcinog Mutagen. 16: 183-98. PMID: 8983120
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Nitroso-N-ethylurea, 10 g | sc-215469 | 10 g | $330.00 | |||
N-Nitroso-N-ethylurea, 100 g | sc-215469A | 100 g | $1600.00 | |||
N-Nitroso-N-ethylurea, 500 g | sc-215469B | 500 g | $6500.00 | |||
N-Nitroso-N-ethylurea, 1 kg | sc-215469C | 1 kg | $9500.00 |