Date published: 2025-10-18

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N,N′,N″,N‴,N⁗,N⁗′-Hexaacetylchitohexaose (CAS 38854-46-5)

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Alternate Names:
N,N′,N′′,N′′′,N′′′′,N′′′′′-Hexaacetylchitohexaose is also known as hexa-N-acetylchitohexaose.
Application:
N,N′,N′′,N′′′,N′′′′,N′′′′′-Hexaacetylchitohexaose is a substrate for human lysozyme, useful for mutagenesis studies.
CAS Number:
38854-46-5
Molecular Weight:
1237.18
Molecular Formula:
C48H80N6O31
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N,N′,N′′,N′′′,N′′′′,N′′′′′-Hexaacetylchitohexaose is a chemically modified oligosaccharide that is utilized extensively in biochemical research to study carbohydrate-protein interactions, particularly those involving chitin and its derivatives. As a soluble analog of chitin, it provides a valuable model for understanding the binding specificity and enzymatic processes related to this naturally occurring polymer. Researchers leverage this hexamer to investigate the substrate specificity of chitinases, enzymes responsible for the degradation of chitin, which is significant for exploring the life cycle of chitin-containing organisms and the development of biocontrol agents. The compound′s acetyl groups enhance its solubility, making it especially useful in in vitro assays to mimic the structure of chitin in a more accessible form. Additionally, it is used in the field of glycobiology to study the structure and function of glycosidic bonds, and to explore the mechanics of glycosylation, a process vital for proper cellular function.


N,N′,N″,N‴,N⁗,N⁗′-Hexaacetylchitohexaose (CAS 38854-46-5) References

  1. NMR and modeling studies of protein-carbohydrate interactions: synthesis, three-dimensional structure, and recognition properties of a minimum hevein domain with binding affinity for chitooligosaccharides.  |  Aboitiz, N., et al. 2004. Chembiochem. 5: 1245-55. PMID: 15368576
  2. Hevein domains: an attractive model to study carbohydrate-protein interactions at atomic resolution.  |  Jiménez-Barbero, J., et al. 2006. Adv Carbohydr Chem Biochem. 60: 303-54. PMID: 16750446
  3. Measuring protein-ligand interactions using liquid sample desorption electrospray ionization mass spectrometry.  |  Liu, P., et al. 2013. Anal Chem. 85: 11966-72. PMID: 24237005
  4. Electrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomics.  |  Paleček, E., et al. 2015. Chem Rev. 115: 2045-108. PMID: 25659975
  5. Structural Insight into Fungal Cell Wall Recognition by a CVNH Protein with a Single LysM Domain.  |  Koharudin, LM., et al. 2015. Structure. 23: 2143-54. PMID: 26455798
  6. A Structurally Novel Chitinase from the Chitin-Degrading Hyperthermophilic Archaeon Thermococcus chitonophagus.  |  Horiuchi, A., et al. 2016. Appl Environ Microbiol. 82: 3554-3562. PMID: 27060120
  7. Crystal structures of an archaeal chitinase ChiD and its ligand complexes.  |  Nishitani, Y., et al. 2018. Glycobiology. 28: 418-426. PMID: 29800365
  8. Role of lysine residues of the Magnaporthe oryzae effector AvrPiz-t in effector- and PAMP-triggered immunity.  |  Bai, P., et al. 2019. Mol Plant Pathol. 20: 599-608. PMID: 30548752
  9. Cyclic and square wave voltammetry of chitooligosaccharides modified by osmium(VI) tetramethylethylenediamine.  |  Trefulka, M. and Ostatná, V. 2020. Bioelectrochemistry. 133: 107494. PMID: 32120319
  10. The 1.8 A resolution structure of hevamine, a plant chitinase/lysozyme, and analysis of the conserved sequence and structure motifs of glycosyl hydrolase family 18.  |  Terwisscha van Scheltinga, AC., et al. 1996. J Mol Biol. 262: 243-57. PMID: 8831791

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N,N′,N″,N‴,N⁗,N⁗′-Hexaacetylchitohexaose, 1 mg

sc-222018
1 mg
$224.00

N,N′,N″,N‴,N⁗,N⁗′-Hexaacetylchitohexaose, 5 mg

sc-222018A
5 mg
$408.00

N,N′,N″,N‴,N⁗,N⁗′-Hexaacetylchitohexaose, 25 mg

sc-222018B
25 mg
$1846.00