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N,N′-Ethylenebis(iodoacetamide) (CAS 7250-43-3)

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Alternate Names:
N,N′-1,2-ethanediylbis(2-iodoacetamide); EBI
Application:
N,N′-Ethylenebis(iodoacetamide) is A homobifunctional sulfhydryl-reactive crosslinker
CAS Number:
7250-43-3
Purity:
≥95%
Molecular Weight:
395.96
Molecular Formula:
C6H10I2N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N,N′-Ethylenebis(iodoacetamide) is a homobifunctional sulfhydryl-reactive crosslinker. It has been used to conjugate groups in tubulin and can therefore be used as a probe for the conformational state of the tubulin molecule. N,N′-Ethylenebis(iodoacetamide) is a synthetic compound with versatile applications in chemical processes, including synthesis, purification, and analytical techniques. As an organoiodine compound, it has found utility in numerous laboratory experiments. In organic chemistry, it serves as a valuable reagent, catalyzing various reactions such as the formation of aldehydes, ketones, and carboxylic acids. Moreover, in biochemistry, it proves beneficial as a ligand for metal ions, enabling protein modification and manipulation.


N,N′-Ethylenebis(iodoacetamide) (CAS 7250-43-3) References

  1. Interaction of dolastatin 10 with bovine brain tubulin.  |  Ludueña, RF., et al. 1992. Biochem Pharmacol. 43: 539-43. PMID: 1540211
  2. Tubulin sulfhydryl groups as probes and targets for antimitotic and antimicrotubule agents.  |  Luduena, RF. and Roach, MC. 1991. Pharmacol Ther. 49: 133-52. PMID: 1852786
  3. Effect of phomopsin A on the alkylation of tubulin.  |  Ludueña, RF., et al. 1990. Biochem Pharmacol. 39: 1603-8. PMID: 2337418
  4. Interaction of rhizoxin with bovine brain tubulin.  |  Sullivan, AS., et al. 1990. Cancer Res. 50: 4277-80. PMID: 2364385
  5. Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach.  |  Canela, MD., et al. 2014. J Med Chem. 57: 3924-38. PMID: 24773591
  6. SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines.  |  Yan, W., et al. 2018. Cell Physiol Biochem. 47: 489-504. PMID: 29794416
  7. 4'-O-Methylbroussochalcone B as a novel tubulin polymerization inhibitor suppressed the proliferation and migration of acute myeloid leukaemia cells.  |  Liu, Z., et al. 2021. BMC Cancer. 21: 91. PMID: 33482772
  8. Structural differences between brain beta 1- and beta 2-tubulins: implications for microtubule assembly and colchicine binding.  |  Little, M. and Ludueña, RF. 1985. EMBO J. 4: 51-6. PMID: 4018027
  9. N,N'-Ethylene-bis(iodoacetamide) as a probe for structural and functional characteristics of brine shrimp, squid, and bovine tubulins.  |  Luduena, RF., et al. 1985. Can J Biochem Cell Biol. 63: 439-47. PMID: 4041960
  10. Interactions of the tau-tubulin-vinblastine complex with colchicine, podophyllotoxin, and N,N'-ethylenebis(iodoacetamide).  |  Palanivelu, P. and Ludueña, RF. 1982. J Biol Chem. 257: 6311-5. PMID: 6804464
  11. Interaction of tubulin with drugs and alkylating agents. 1. Alkylation of tubulin by iodo[14C]acetamide and N,N'-ethylenebis(iodoacetamide).  |  Ludueña, RF. and Roach, MC. 1981. Biochemistry. 20: 4437-44. PMID: 7284333
  12. Interaction of ethacrynic acid with bovine brain tubulin.  |  Ludueña, RF., et al. 1994. Biochem Pharmacol. 47: 1677-81. PMID: 8185683
  13. The colchicine-binding and pyrene-excimer-formation activities of tubulin involve a common cysteine residue in the beta subunit.  |  Basusarkar, P., et al. 1997. Eur J Biochem. 244: 378-83. PMID: 9119003

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N,N′-Ethylenebis(iodoacetamide), 100 mg

sc-215511
100 mg
$438.00