N-(n-Nonyl)deoxynojirimycin (CAS 81117-35-3)
QUICK LINKS
N-(n-Nonyl)deoxynojirimycin is a chemically significant compound that has been the focus of research for its potential medicinal applications. Derived from piperidine, a cyclic organic compound found in nature, N-(n-Nonyl)deoxynojirimycin has been subject to investigations as an enzyme inhibitor and its interactions with various biological molecules. Scientific research has extensively explored the potential medicinal applications of N-(n-Nonyl)deoxynojirimycin through both in vivo and in vitro experiments. In vivo experiments employ animal models, while in vitro experiments involve the use of cell cultures or isolated tissues. N-(n-Nonyl)deoxynojirimycin is believed to act as an enzyme inhibitor by binding to and inhibiting the activity of cyclooxygenase-2. Additionally, its interactions with other proteins and enzymes may lead to diverse biological effects.
N-(n-Nonyl)deoxynojirimycin (CAS 81117-35-3) References
- The alkylated imino sugar, n-(n-Nonyl)-deoxygalactonojirimycin, reduces the amount of hepatitis B virus nucleocapsid in tissue culture. | Lu, X., et al. 2003. J Virol. 77: 11933-40. PMID: 14581530
- Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. | Mu, TW., et al. 2008. PLoS Biol. 6: e26. PMID: 18254660
- Chemical and biological approaches synergize to ameliorate protein-folding diseases. | Mu, TW., et al. 2008. Cell. 134: 769-81. PMID: 18775310
- Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening. | Urban, DJ., et al. 2008. Comb Chem High Throughput Screen. 11: 817-24. PMID: 19075603
- Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)deoxynojirimycin. | Luan, Z., et al. 2009. Chembiochem. 10: 2780-92. PMID: 19830760
- Emergence and natural selection of drug-resistant prions. | Shorter, J. 2010. Mol Biosyst. 6: 1115-30. PMID: 20422111
- High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase. | Goldin, E., et al. 2012. PLoS One. 7: e29861. PMID: 22272254
- Pharmacological chaperones facilitate the post-ER transport of recombinant N370S mutant β-glucocerebrosidase in plant cells: evidence that N370S is a folding mutant. | Babajani, G., et al. 2012. Mol Genet Metab. 106: 323-9. PMID: 22592100
- Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase. | Patnaik, S., et al. 2012. J Med Chem. 55: 5734-48. PMID: 22646221
- The relationship between glucocerebrosidase mutations and Parkinson disease. | Migdalska-Richards, A. and Schapira, AH. 2016. J Neurochem. 139 Suppl 1: 77-90. PMID: 26860875
- A direct role for hepatitis B virus X protein in inducing mitochondrial membrane permeabilization. | Lee, HR., et al. 2018. J Viral Hepat. 25: 412-420. PMID: 29193612
- Diagnosing neuronopathic Gaucher disease: New considerations and challenges in assigning Gaucher phenotypes. | Daykin, EC., et al. 2021. Mol Genet Metab. 132: 49-58. PMID: 33483255
- Precision Medicine in Parkinson's Disease: From Genetic Risk Signals to Personalized Therapy. | Straccia, G., et al. 2022. Brain Sci. 12: PMID: 36291241
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-(n-Nonyl)deoxynojirimycin, 5 mg | sc-219388 | 5 mg | $164.00 | |||
N-(n-Nonyl)deoxynojirimycin, 25 mg | sc-219388A | 25 mg | $640.00 |