Date published: 2025-12-18

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N,N-Dimethylglycine (CAS 1118-68-9)

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Alternate Names:
(Dimethylamino)acetic acid
Application:
N,N-Dimethylglycine is a natural N-methylated glycine
CAS Number:
1118-68-9
Purity:
≥98%
Molecular Weight:
103.12
Molecular Formula:
C4H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N,N-Dimethylglycine is a compound studied extensively in the fields of biochemistry and organic chemistry. Researchers are interested in its properties as a tertiary amine and its role in biological systems as a substrate and intermediate in metabolic pathways. In biochemistry, N,N-Dimethylglycine is used to explore its participation in the metabolism of choline and to understand its biochemical transformations. It is also a subject of interest in studies focusing on the methyl donation processes, which are for many biosynthetic reactions. In organic synthesis, this compound is investigated for its potential in the preparation of more complex organic molecules, serving as a building block due to its functional groups that allow for various chemical modifications.


N,N-Dimethylglycine (CAS 1118-68-9) References

  1. Gas-phase structure of N,N-dimethylglycine.  |  Lesarri, A., et al. 2005. Chemphyschem. 6: 1559-66. PMID: 15999385
  2. Effects of N, N-dimethylglycine on the development of in vitro produced bovine embryos.  |  Takahashi, T., et al. 2009. J Reprod Dev. 55: 339-42. PMID: 19305128
  3. Characterization of osmolyte betaine synthesizing sarcosine dimethylglycine N-methyltransferase from Methanohalophilus portucalensis.  |  Chen, SY., et al. 2009. Arch Microbiol. 191: 735-43. PMID: 19693490
  4. Effect of N,N-dimethylglycine supplementation in parturition feed for sows on metabolism, nutrient digestibility and reproductive performance.  |  Cools, A., et al. 2010. Animal. 4: 2004-11. PMID: 22445374
  5. N, N-Dimethylglycine decreases oxidative stress and improves in vitro development of bovine embryos.  |  Takahashi, T., et al. 2016. J Reprod Dev. 62: 209-12. PMID: 26875568
  6. N,N-dimethylglycine differentially modulates psychotomimetic and antidepressant-like effects of ketamine in mice.  |  Lin, JC., et al. 2016. Prog Neuropsychopharmacol Biol Psychiatry. 71: 7-13. PMID: 27296677
  7. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials.  |  Lee, MY., et al. 2017. J Biomed Sci. 24: 18. PMID: 28245819
  8. The Role of N,N,N-Trimethylglycine in Oviposition of Eurema mandarina on Albizia julibrissin.  |  Ohashi, T., et al. 2019. J Chem Ecol. 45: 371-377. PMID: 30880353
  9. Nitrogen source-dependent inhibition of yeast growth by glycine and its N-methylated derivatives.  |  Linder, T. 2020. Antonie Van Leeuwenhoek. 113: 437-445. PMID: 31630298
  10. Role of N,N-Dimethylglycine and Its Catabolism to Sarcosine in Chromohalobacter salexigens DSM 3043.  |  Yang, T., et al. 2020. Appl Environ Microbiol. 86: PMID: 32631860
  11. N,N-dimethylglycine prevents toluene-induced impairment in recognition memory and synaptic plasticity in mice.  |  Hsieh, CP., et al. 2020. Toxicology. 446: 152613. PMID: 33086094
  12. Observation of Conformational Simplification upon N-Methylation on Amino Acid Iodide Clusters.  |  Cao, W., et al. 2021. J Phys Chem Lett. 12: 2780-2787. PMID: 33710892
  13. Effect of N, N-Dimethylglycine on Homocysteine Metabolism in Rats Fed Folate-Sufficient and Folate-Deficient Diets.  |  Liu, YQ., et al. 2021. Biomed Environ Sci. 34: 356-363. PMID: 34059172
  14. N, N-dimethylglycine Protects Behavioral Disturbances and Synaptic Deficits Induced by Repeated Ketamine Exposure in Mice.  |  Hsieh, CP., et al. 2021. Neuroscience. 472: 128-137. PMID: 34400248
  15. The metabolomic profiling identifies N, N-dimethylglycine as a facilitator of dorsal root ganglia neuron axon regeneration after injury.  |  Zhang, J., et al. 2022. FASEB J. 36: e22305. PMID: 35394692

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N,N-Dimethylglycine, 10 mg

sc-215499
10 mg
$25.00

N,N-Dimethylglycine, 5 g

sc-215499A
5 g
$76.00

N,N-Dimethylglycine, 500 g

sc-215499B
500 g
$311.00

N,N-Dimethylglycine, 1 kg

sc-215499C
1 kg
$525.00