N,N-Dimethylformamide (CAS 68-12-2)

N,N-Dimethylformamide (DMF), with the CAS number 68-12-2, is a polar organic solvent featuring a high boiling point and the ability to dissolve a wide range of substances, making it extremely useful in various chemical and industrial applications. Chemically, it is an amide compound, consisting of a formamide (HCONH2) backbone where both hydrogens of the amide group are replaced by methyl groups, enhancing its solvent capabilities. DMF′s exceptional solvency properties stem from its ability to engage in hydrogen bonding with solute molecules, thereby effectively solubilizing compounds that are otherwise difficult to dissolve. This characteristic is crucial in the synthesis and purification of peptides and other small molecules, where it facilitates reactions by improving the solubility of reactants. In research, DMF is particularly valued for its role in facilitating the reaction conditions in the synthesis of pharmaceuticals and polymers, acting not only as a solvent but also occasionally participating in reactions as a reagent. For example, its use in the Swern oxidation demonstrates its utility as a reaction medium that can stabilize reactive intermediates. Moreover, DMF is also used in the production of fibers, films, and surface coatings, where its ability to dissolve a vast range of materials and assist in the formation of homogeneous mixtures is essential. Its versatility and efficacy in improving reaction outcomes make it an indispensable tool in both academic and industrial chemical laboratories.