Molecular structure of N,N-Diisopropylmethylphosphonamidic chloride, CAS Number: 86030-43-5
N,N-Diisopropylmethylphosphonamidic chloride (CAS 86030-43-5)
Application:
N,N-Diisopropylmethylphosphonamidic chloride is a phosphitylating agent used in the synthesis of oligonucleotides
CAS Number:
86030-43-5
Purity:
95%
Molecular Weight:
197.64
Molecular Formula:
C7H17ClNOP
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N,N-Diisopropylmethylphosphonamidic chloride is phosphitylating agent employed in the synthesis of oligonucleotides by the phosphoramidite method. It is thought to function as both a proton acceptor and a nucleophile within diverse reaction contexts. Furthermore, in specific reactions like the Wittig reaction, it is thought to adopt the role of an electrophile, exemplifying its dynamic reactivity across various chemical processes.
N,N-Diisopropylmethylphosphonamidic chloride (CAS 86030-43-5) References
- Chemical syntheses of inhibitory substrates of the RNA-RNA ligation reaction catalyzed by the hairpin ribozyme. | Massey, AP. and Sigurdsson, ST. 2004. Nucleic Acids Res. 32: 2017-22. PMID: 15064361
- Synthesis and physical and physiological properties of 4'-thioRNA: application to post-modification of RNA aptamer toward NF-kappaB. | Hoshika, S., et al. 2004. Nucleic Acids Res. 32: 3815-25. PMID: 15263062
- Synthesis and characterization of a ribavirin-3',5'-phosphate pentadecamer homoribopolymer bearing a 5'-amino tether group and a 3'-thymidine. | Dawson, MI., et al. 1990. Nucleic Acids Res. 18: 1099-102. PMID: 2320410
- Synthesis of Oligonucleotides Containing the N6 -(2-Deoxy-α,β-d-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy⋅dG) Oxidative Damage Product Derived from 2'-Deoxyguanosine. | Yang, H., et al. 2020. Chemistry. 26: 5441-5448. PMID: 32271495
- A Trisbenzimidazole Phosphoramidite Building Block Enables High-Yielding Syntheses of RNA-Cleaving Oligonucleotide Conjugates. | Zellmann, F. and Göbel, MW. 2020. Molecules. 25: PMID: 32316292
- The synthesis of oligonucleotides containing a primary amino group at the 5'-terminus. | Connolly, BA. 1987. Nucleic Acids Res. 15: 3131-9. PMID: 3562247
- Prevention of guanine modification and chain cleavage during the solid phase synthesis of oligonucleotides using phosphoramidite derivatives. | Pon, RT., et al. 1986. Nucleic Acids Res. 14: 6453-70. PMID: 3748816
- Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines. | Sanghvi, YS., et al. 1993. Nucleic Acids Res. 21: 3197-203. PMID: 8393563
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N,N-Diisopropylmethylphosphonamidic chloride, 1 g | sc-253138 | 1 g | $75.00 |