Date published: 2025-11-20

1-800-457-3801

SCBT Portrait Logo
Seach Input

N,N-Bis(2-chloroethyl)phosphorodiamidic Acid Cyclohexylamine Salt (CAS 1566-15-0)

0.0(0)
Write a reviewAsk a question

Alternate Names:
Phosphamide Mustard; NSC 69945
CAS Number:
1566-15-0
Molecular Weight:
320.2
Molecular Formula:
C10H24Cl2N3O2P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

N,N-Bis(2-chloroethyl)phosphorodiamidic acid cyclohexylamine salt is a chemical utilized in synthetic organic chemistry, primarily as a reagent in the synthesis of phosphorodiamidate-based compounds. Its structure contains two 2-chloroethyl groups attached to a phosphorodiamidic acid, which can participate in nucleophilic substitution reactions. The cyclohexylamine salt form of this compound improves its solubility in organic solvents, facilitating its use in various reaction conditions. Researchers are interested in this compound for its potential to act as an intermediate in producing phosphoramidate analogs, which are relevant in the study of organophosphorus chemistry. Studies involving N,N-Bis(2-chloroethyl)phosphorodiamidic acid cyclohexylamine salt also contribute to the understanding of the reactivity and stability of phosphoramidates, which is significant for the development of compounds with potential applications in materials science and catalysis. Additionally, the compound′s bifunctional nature allows for the exploration of cross-linking reactions in polymer chemistry, where it may be used to modify the properties of polymeric materials.


N,N-Bis(2-chloroethyl)phosphorodiamidic Acid Cyclohexylamine Salt (CAS 1566-15-0) References

  1. Identification of phosphorodiamidic acid mustard as a human metabolite of cyclop hosphamide.  |  Fenselau, C., et al. 1975. Cancer Res. 35: 1453-7. PMID: 1131817
  2. Comparative pharmacologic study in vitro and in vivo with cyclophosphamide (NSC-26271), cyclophosphamide metabolites, and plain nitrogen mustard compounds.  |  Brock, N. 1976. Cancer Treat Rep. 60: 301-8. PMID: 1277205
  3. NUCLEAR MAGNETIC RESONANCE STUDY OF STABILITY OF SALT OF N, N-BIS(2-CHLOROETHYL)PHOSPHORODIAMIDIC ACID (NSC-69945) IN AQUEOUS SOLUTION.  |  LEVINS, PL. and ROGERS, WI. 1965. Cancer Chemother Rep. 44: 15-7. PMID: 14298876
  4. Effects of alkylating metabolites of ifosfamide and its bromo analogues on DNA of HeLa cells.  |  Studzian, K., et al. 1992. Biochem Pharmacol. 43: 937-43. PMID: 1554391
  5. Covalent DNA-Protein Cross-Linking by Phosphoramide Mustard and Nornitrogen Mustard in Human Cells.  |  Groehler, A., et al. 2016. Chem Res Toxicol. 29: 190-202. PMID: 26692166
  6. O-imino esters of N,N-bis(2-chloroethyl)phosphorodiamidic acid. Synthesis, X-ray structure determination, and anticancer evaluation.  |  Ludeman, SM., et al. 1983. J Med Chem. 26: 1788-90. PMID: 6644750

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N,N-Bis(2-chloroethyl)phosphorodiamidic Acid Cyclohexylamine Salt, 5 mg

sc-503798
5 mg
$400.00

N,N-Bis(2-chloroethyl)phosphorodiamidic Acid Cyclohexylamine Salt, 50 mg

sc-503798A
50 mg
$2910.00