Date published: 2025-9-27

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N-Methylacetamide (CAS 79-16-3)

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Alternate Names:
Acetylmethylamine
CAS Number:
79-16-3
Molecular Weight:
73.09
Molecular Formula:
C3H7NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-Methylacetamide is a compound that functions as a solvent in various chemical reactions and processes. It plays a role in facilitating the dissolution and mixing of different substances, allowing for efficient and effective reactions to take place. At the molecular level, N-Methylacetamide interacts with other compounds by forming hydrogen bonds, which may influence the reaction kinetics and thermodynamics. N-Methylacetamide′s mechanism of action involves its ability to stabilize reaction intermediates and transition states, thereby promoting the progression of chemical reactions. N-Methylacetamide′s solvent properties make it a useful component in experimental setups where controlled and homogeneous reaction conditions are required.


N-Methylacetamide (CAS 79-16-3) References

  1. Cryoprotectant toxicity neutralization.  |  Fahy, GM. 2010. Cryobiology. 60: S45-53. PMID: 19501081
  2. Formation of a dual hydrogen bond in the N-H..C=O moiety in the indole-(N-methylacetamide)1 cluster revealed by IR-dip spectroscopy with natural bond orbital analysis.  |  Sakota, K., et al. 2009. J Chem Phys. 130: 231105. PMID: 19548704
  3. Chlorination of N-methylacetamide and amide-containing pharmaceuticals. Quantum-chemical study of the reaction mechanism.  |  Šakić, D., et al. 2014. J Phys Chem A. 118: 2367-76. PMID: 24601593
  4. Experimental and theoretical XPS and NEXAFS studies of N-methylacetamide and N-methyltrifluoroacetamide.  |  Li, C., et al. 2016. Phys Chem Chem Phys. 18: 2210-8. PMID: 26691541
  5. Interplay between Hydrogen Bonding and Vibrational Coupling in Liquid N-Methylacetamide.  |  Cunha, AV., et al. 2017. J Phys Chem Lett. 8: 2438-2444. PMID: 28510458
  6. Hydrophobic Collapse in N-Methylacetamide-Water Mixtures.  |  Salamatova, E., et al. 2018. J Phys Chem A. 122: 2468-2478. PMID: 29425450
  7. N-Methylacetamide Aqueous Solutions: A Neutron Diffraction Study.  |  Di Gioacchino, M., et al. 2019. J Phys Chem B. 123: 1808-1814. PMID: 30739453
  8. A neural network protocol for electronic excitations of N-methylacetamide.  |  Ye, S., et al. 2019. Proc Natl Acad Sci U S A. 116: 11612-11617. PMID: 31147467
  9. Effect of dimethylacetamide and N-methylacetamide on the quality and fertility of frozen/thawed chicken semen.  |  Mosca, F., et al. 2019. Poult Sci. 98: 6071-6077. PMID: 31180125
  10. DFT-Calculated IR Spectrum Amide I, II, and III Band Contributions of N-Methylacetamide Fine Components.  |  Ji, Y., et al. 2020. ACS Omega. 5: 8572-8578. PMID: 32337419
  11. Effect of N-Methylacetamide Concentration and Thawing Rate on Chicken Sperm Quality after Cryopreservation.  |  Mosca, F., et al. 2020. Animals (Basel). 10: PMID: 32397424
  12. Concentration dependent effect of dimethylacetamide and N-methylacetamide on the quality and fertility of cryopreserved chicken semen.  |  Zaniboni, L., et al. 2022. Cryobiology. 106: 66-72. PMID: 35429488
  13. Flow cytometry data on the effect of dimethylacetamide and N-methylacetamide used at different concentrations on the quality of cryopreserved chicken semen.  |  Madeddu, M., et al. 2023. Data Brief. 47: 108916. PMID: 36747977

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Methylacetamide, 5 g

sc-250473
5 g
$20.00

N-Methylacetamide, 100 g

sc-250473A
100 g
$26.00