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N-Methyl-DL-aspartic acid (CAS 17833-53-3)

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Alternate Names:
N-Me-DL-Asp-OH; (R,S)-2-(Methylamino)succinic acid
CAS Number:
17833-53-3
Molecular Weight:
147.13
Molecular Formula:
C5H9NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-Methyl-DL-aspartic acid is an amino acid that mimics the action of glutamate. Its mode of action involves the activation of a distinct subtype of glutamate receptor called the N-Methyl-DL-aspartic acid receptor. The N-methyl group added to aspartic acid significantly alters its interactions with glutamate receptors, particularly the N-Methyl-DL-aspartic acid receptor. N-Methyl-DL-aspartic acid receptors play a key role in synaptic plasticity. The binding of N-Methyl-DL-aspartic acid to this receptor initiates a series of interconnected biochemical and physiological processes, contributing to diverse physiological effects. These effects encompass alterations in gene expression, modulation of neurotransmitter levels, and modulation of the activity of other receptors.


N-Methyl-DL-aspartic acid (CAS 17833-53-3) References

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  2. Morphological evidence that xenon neuroprotects against N-methyl-DL-aspartic acid-induced damage in the rat arcuate nucleus: a time-dependent study.  |  Natale, G., et al. 2006. Ann N Y Acad Sci. 1074: 650-8. PMID: 17105960
  3. Anticonvulsant activity of Cotyledon orbiculata L. (Crassulaceae) leaf extract in mice.  |  Amabeoku, GJ., et al. 2007. J Ethnopharmacol. 112: 101-7. PMID: 17398051
  4. The Effect of intravitreal N-methyl-DL-aspartic acid on the electroretinogram in Royal College of surgeons rats.  |  Ohzeki, T., et al. 2007. Jpn J Ophthalmol. 51: 165-74. PMID: 17554477
  5. Anticonvulsant activity of Nylandtia spinosa L. Dumont (Polygalaceae) aqueous and methanol leaf extracts in mice.  |  Amabeoku, G. 2008. Hum Exp Toxicol. 27: 811-8. PMID: 19244288
  6. Pharmacological dissection of multifocal electroretinograms of rabbits with Pro347Leu rhodopsin mutation.  |  Yokoyama, D., et al. 2010. Jpn J Ophthalmol. 54: 458-66. PMID: 21052910
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  8. Contribution of N-methyl-DL-aspartic acid (NMDA)-sensitive neurons to generating oscillatory potentials in Royal College of Surgeons rats.  |  Harada, T., et al. 2013. Doc Ophthalmol. 127: 131-40. PMID: 23744447
  9. Sustained intermittent release of gonadotropin-releasing hormone in the prepubertal male rhesus monkey induced by N-methyl-DL-aspartic acid.  |  Gay, VL. and Plant, TM. 1988. Neuroendocrinology. 48: 147-52. PMID: 3065674
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  11. Effects of excitatory amino acids on locomotor activity after bilateral microinjection into the rat nucleus accumbens: possible dependence on dopaminergic mechanisms.  |  Donzanti, BA. and Uretsky, NJ. 1983. Neuropharmacology. 22: 971-81. PMID: 6137783
  12. Ethanol alters N-methyl-DL-aspartic acid-induced secretion of luteinizing hormone releasing hormone and the onset of puberty in the female rat.  |  Nyberg, CL., et al. 1993. Neuroendocrinology. 57: 863-8. PMID: 8413822
  13. Intracaudate injection of N-methyl-dl-aspartic acid inhibits cortical evoked potentials.  |  Roemer, RA., et al. 1977. Physiol Behav. 18: 225-9. PMID: 866460
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  15. N-methyl-DL-aspartic acid lesions of the medial preoptic area disrupt ongoing parental behavior in male rats.  |  Sturgis, JD. and Bridges, RS. 1997. Physiol Behav. 62: 305-10. PMID: 9251972

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Methyl-DL-aspartic acid, 1 g

sc-472356
1 g
$49.00

N-Methyl-DL-aspartic acid, 5 g

sc-472356A
5 g
$156.00

N-Methyl-DL-aspartic acid, 25 g

sc-472356B
25 g
$624.00