Molecular structure of N-Isobutyryl-L-cysteine, CAS Number: 124529-02-8
N-Isobutyryl-L-cysteine (CAS 124529-02-8)
Alternate Names:
N-(2-Methylpropionyl)-L-cysteine
Application:
N-Isobutyryl-L-cysteine is an agent for chiral derivitization
CAS Number:
124529-02-8
Purity:
≥97%
Molecular Weight:
191.25
Molecular Formula:
C7H13NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Isobutyryl-L-cysteine is a thiol compound, which distinguishes chirality in assays involving amino acids with OPA. N-Isobutyryl-L-cysteine is employed along with gold particles on a monolayer surface to separate single stranded DNA, via the interaction between the dipole moment of N-Isobutyryl-L-cysteine and the negative charge of single stranded DNA. These studies determined that N-Isobutyryl-L-cysteine is an essential tool along with gold nanoparticles in vibrational circular dichroism (VCD) and circular dichroism (CD) spectroscopy. Furthermore, the L isomer is more effective in adsorption of relaxed DNA compared to the D form which causes DNA to supercoil and results in a weaker binding strength.
N-Isobutyryl-L-cysteine (CAS 124529-02-8) References
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- Selective adsorption of DNA on chiral surfaces: supercoiled or relaxed conformation. | Gan, H., et al. 2009. Angew Chem Int Ed Engl. 48: 5282-6. PMID: 19308941
- Single-stranded DNA adsorption on chiral molecule coated Au surface: a molecular dynamics study. | Liang, H., et al. 2010. Phys Chem Chem Phys. 12: 4431-4. PMID: 20407716
- Automated enantioseparation of amino acids by derivatization with o-phthaldialdehyde and n-acylated cysteines. | Brückner, H., et al. 1989. J Chromatogr. 476: 73-82. PMID: 2777997
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- Determination of Hepatoma-Associated DL-Amino Acids Enantiomers by RP-HPLC with Fluorescence Detector: Application in Patients with Hepatocellular Carcinoma. | Sun, H., et al. 2018. Ann Clin Lab Sci. 48: 490-495. PMID: 30143491
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- Origins and characteristics of dissolved organic matter fueling harmful dinoflagellate blooms revealed by δ13C and D/L-Amino acid compositions. | Park, J., et al. 2022. Sci Rep. 12: 15052. PMID: 36064561
- Polyacrylamide gel electrophoresis: a versatile tool for the separation of nanoclusters. | Packirisamy, V. and Pandurangan, P. 2023. Biotechniques. 74: 51-62. PMID: 36517970
- Trends in Drug Delivery Systems for Natural Bioactive Molecules to Treat Health Disorders: The Importance of Nano-Liposomes. | Cardoso, RV., et al. 2022. Pharmaceutics. 14: PMID: 36559301
- Viewing Aggregation-Induced Emission of Metal Nanoclusters from Design Strategies to Applications. | Li, T., et al. 2023. Nanomaterials (Basel). 13: PMID: 36770433
- Liquid chromatographic determination of D- and L-amino acids by derivatization with o-phthaldialdehyde and N-isobutyryl-L-cysteine. Applications with reference to the analysis of peptidic antibiotics, toxins, drugs and pharmaceutically used amino acids. | Brückner, H., et al. 1995. J Chromatogr A. 711: 201-15. PMID: 7496491
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Isobutyryl-L-cysteine, 250 mg | sc-253113 | 250 mg | $85.00 | |||
N-Isobutyryl-L-cysteine, 1 g | sc-253113A | 1 g | $282.00 |