Date published: 2026-4-4

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N-Iodosuccinimide (CAS 516-12-1)

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Application:
N-Iodosuccinimide is a reagent for the oxidimetric titration of sulfur functions, oxidations, and iodinations
CAS Number:
516-12-1
Molecular Weight:
224.98
Molecular Formula:
C4H4INO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-Iodosuccinimide is a reagent for the oxidimetric titration of sulfur functions, oxidations, and iodinations.


N-Iodosuccinimide (CAS 516-12-1) References

  1. Determination of sulphur functions with N-iodosuccinimide.  |  Srivastava, A. 1979. Talanta. 26: 917-20. PMID: 18962543
  2. Umpolung amide synthesis using substoichiometric N-iodosuccinimide (NIS) and oxygen as a terminal oxidant.  |  Schwieter, KE., et al. 2014. Org Lett. 16: 4714-7. PMID: 25198239
  3. Highly Regioselective Iodination of Arenes via Iron(III)-Catalyzed Activation of N-Iodosuccinimide.  |  Racys, DT., et al. 2015. Org Lett. 17: 4782-5. PMID: 26394175
  4. N-Iodosuccinimide involved one-pot metal-free synthesis of 2-heteroaromatic benzothiazole compounds.  |  Chu, X., et al. 2017. Org Biomol Chem. 15: 1606-1611. PMID: 28116402
  5. Preparation of 3-Iodoquinolines from N-Tosyl-2-propynylamines with Diaryliodonium Triflate and N-Iodosuccinimide.  |  Sasaki, T., et al. 2017. J Org Chem. 82: 11727-11734. PMID: 28718287
  6. Straightforward S-S Bond Formation via the Oxidation of S-Acetyl by Iodine in the Presence of N-Iodosuccinimide.  |  Ge, JT., et al. 2017. J Org Chem. 82: 12613-12623. PMID: 29084384
  7. Trifluoromethylation of Unactivated Alkenes with Me3SiCF3 and N-Iodosuccinimide.  |  Yang, X. and Tsui, GC. 2019. Org Lett. 21: 1521-1525. PMID: 30777764
  8. A novel approach for the detection and identification of sulfur mustard using liquid chromatography-electrospray ionization-tandem mass spectrometry based on its selective oxidation to sulfur mustard monoxide with N-iodosuccinimide.  |  Prihed, H., et al. 2021. J Mass Spectrom. 56: e4721. PMID: 33848030
  9. Intramolecular C-H Amination of N-Alkylsulfamides by tert-Butyl Hypoiodite or N-Iodosuccinimide.  |  Kiyokawa, K., et al. 2021. Chemistry. 27: 13971-13976. PMID: 34403187
  10. A pentacarbomethoxycyclopentadiene (PCCP) organic Brønsted acid catalyzed stereoselective glycosidation of N-pentenyl orthoesters (NPOE) of d-glucose and d-galactose, in conjunction with N-iodosuccinimide.  |  Aswathy, M., et al. 2022. Carbohydr Res. 522: 108684. PMID: 36193594

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Iodosuccinimide, 5 g

sc-255356
5 g
$48.00

N-Iodosuccinimide, 25 g

sc-255356A
25 g
$179.00