Date published: 2025-10-31

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N-hexanoyl-L-Homoserine lactone (CAS 147852-83-3)

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Alternate Names:
C6-HSL; N-[(3S)-tetrahydro-2-oxo-3-furanyl]-hexanamide
Application:
N-hexanoyl-L-Homoserine lactone is a small diffusible signaling molecule
CAS Number:
147852-83-3
Purity:
≥95%
Molecular Weight:
199.2
Molecular Formula:
C10H17NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-hexanoyl-L-Homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and affecting cellular metabolism. This molecule regulates virulence in general and in cystic fibrosis, prevents infection, reduces slime and biofilm in commercial agriculture. In aquaculture industries it is used to prevented food spoilage and septicemia in fish.


N-hexanoyl-L-Homoserine lactone (CAS 147852-83-3) References

  1. N-hexanoyl-L-homoserine lactone, a mediator of bacterial quorum-sensing regulation, exhibits plant-dependent stability and may be inactivated by germinating Lotus corniculatus seedlings.  |  Delalande, L., et al. 2005. FEMS Microbiol Ecol. 52: 13-20. PMID: 16329888
  2. Infrared study of the bacterial autoinducer N-hexanoyl-homoserine lactone (C6-HSL) in the gas-phase, water, and octanol solutions.  |  Kim, J., et al. 2011. J Phys Chem A. 115: 9199-206. PMID: 21786794
  3. Atomic force microscopy reveals a morphological differentiation of chromobacterium violaceum cells associated with biofilm development and directed by N-hexanoyl-L-homoserine lactone.  |  Kamaeva, AA., et al. 2014. PLoS One. 9: e103741. PMID: 25111599
  4. Characterization of N-Acylhomoserine Lactones Produced by Bacteria Isolated from Industrial Cooling Water Systems.  |  Okutsu, N., et al. 2015. Sensors (Basel). 16: PMID: 26729121
  5. The Addition of N-Hexanoyl-Homoserine Lactone to Improve the Microbial Flocculant Production of Agrobacterium tumefaciens Strain F2, an Exopolysaccharide Bioflocculant-Producing Bacterium.  |  Yang, J., et al. 2016. Appl Biochem Biotechnol. 179: 728-39. PMID: 26922725
  6. Exogenous N-acyl homoserine lactones facilitate microbial adhesion of high ammonia nitrogen wastewater on biocarrier surfaces.  |  Peng, P., et al. 2018. Sci Total Environ. 624: 1013-1022. PMID: 29929218
  7. Priming winter wheat seeds with the bacterial quorum sensing signal N-hexanoyl-L-homoserine lactone (C6-HSL) shows potential to improve plant growth and seed yield.  |  Moshynets, OV., et al. 2019. PLoS One. 14: e0209460. PMID: 30802259
  8. Effects of exogenous N-acyl-homoserine lactones on nutrient removal, sludge properties and microbial community structures during activated sludge process.  |  Yan, X., et al. 2020. Chemosphere. 255: 126945. PMID: 32388260
  9. Exploring the Influence of Signal Molecules on Marine Biofilms Development.  |  Wang, R., et al. 2020. Front Microbiol. 11: 571400. PMID: 33281767
  10. Quorum sensing-1 signaling of N-hexanoyl-L-homoserine lactone contributes to virulence in avian pathogenic Escherichia coli.  |  Yang, Y., et al. 2021. Arch Microbiol. 203: 6079-6089. PMID: 34545410
  11. Exogenous N-hexanoyl-L-homoserine lactone assists in upflow anaerobic sludge blanket recovery from acetate accumulation via aceticlastic methanogens enrichment.  |  Zhang, Y., et al. 2022. Bioresour Technol. 346: 126600. PMID: 34973403
  12. Effects of different N-acyl-serine lactone signaling molecules on the performance of anaerobic granular sludge.  |  Dang, W., et al. 2022. RSC Adv. 12: 5439-5446. PMID: 35425575
  13. Enhanced CO2 reduction and acetate synthesis in autotrophic biocathode by N-Hexanoyl-L-homoserine lactone (C6HSL)-based quorum-sensing regulation.  |  Zhou, M., et al. 2022. Sci Total Environ. 836: 155724. PMID: 35523344
  14. Aerobic granulation and microbial community succession in sequencing batch reactors treating the low strength wastewater: The dual effects of weak magnetic field and exogenous signal molecule.  |  Chen, R., et al. 2022. Chemosphere. 309: 136762. PMID: 36209862
  15. Metagenomic and extracellular polymeric substances analysis reveals the mechanism of exogenous N-hexanoyl-L-homoserine lactone in alleviating the inhibition of perfluorooctanoic acid on anammox process.  |  Tang, L., et al. 2023. Bioresour Technol. 369: 128482. PMID: 36513308
  16. Effect of the N-hexanoyl-L-homoserine Lactone on the Carbon Fixation Capacity of the Algae-Bacteria System.  |  Liao, L., et al. 2023. Int J Environ Res Public Health. 20: PMID: 36981956

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-hexanoyl-L-Homoserine lactone, 5 mg

sc-205405
5 mg
$57.00

N-hexanoyl-L-Homoserine lactone, 10 mg

sc-205405A
10 mg
$84.00

N-hexanoyl-L-Homoserine lactone, 25 mg

sc-205405B
25 mg
$172.00

N-hexanoyl-L-Homoserine lactone, 50 mg

sc-205405C
50 mg
$325.00