Molecular structure of N G-Nitro-L-arginine, CAS Number: 2149-70-4
N G-Nitro-L-arginine (CAS 2149-70-4)
See product citations (4)
Alternate Names:
N-OMEGA-NITRO-L-ARGININE
Application:
N G-Nitro-L-arginine is an inhibitor of NOS with selectivity for NOS1 and NOS3
CAS Number:
2149-70-4
Molecular Weight:
219.2
Molecular Formula:
C6H13N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N G-Nitro-L-arginine displays potent inhibition of NOS with selectivity for NOS1 and NOS3 over NOS2. It has been observed to inhibit endothelial nitric oxide biosynthesis and decrease radical generation of peroxynitrite ions. Other inhibitory effects demonstrated in experiments include blocking brady-kinin-induced relaxation in dog coronary artery strips and suppressing morphine tolerance in mice. N G-Nitro-L-arginine causes significant vasoconstriction and is utilized in studying nitric oxide as a neuronal messenger.
N G-Nitro-L-arginine (CAS 2149-70-4) References
- Inhibitory mechanism of N(G)-nitro-L-arginine on acetylcholine-induced depressor responses in dogs. | Nakahara, T., et al. 1999. Eur J Pharmacol. 373: 201-5. PMID: 10414440
- Transport of N(G)-nitro-L-arginine across intestinal brush border membranes by Na+ -dependent and Na+-independent amino acid transporters. | Hatanaka, T., et al. 1999. Pharm Res. 16: 1770-4. PMID: 10571285
- Non-contribution of renin-angiotensin system to pressor response to N(G)-nitro-L-arginine in dogs. | Ishikawa, T., et al. 2002. Fundam Clin Pharmacol. 16: 15-21. PMID: 11903508
- Skeletal muscle and jejunal protein synthesis in normal and ethanol-treated rats: the effect of the nitric oxide synthase inhibitors, L-omega-nitro-L-arginine methyl ester and N(G)-nitro-L-arginine in vivo. | Rajendram, R., et al. 2003. Metabolism. 52: 397-401. PMID: 12701048
- The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation. | Clark, CB., et al. 2004. Resuscitation. 60: 351-7. PMID: 15061157
- Renal D-amino acid oxidase mediates chiral inversion of N(G)-nitro-D-arginine. | Xin, YF., et al. 2005. J Pharmacol Exp Ther. 312: 1090-6. PMID: 15496613
- L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. | Moore, PK., et al. 1990. Br J Pharmacol. 99: 408-12. PMID: 2328404
- Inhibitory effects of L-NG-nitro-arginine on the synthesis of EDRF and the cerebroarterial response to vasodilator nerve stimulation. | Toda, N., et al. 1990. Life Sci. 47: 345-51. PMID: 2388535
- Oral N(G)-nitro-L-arginine in conscious dogs: 24 hour hypertensive response in relation to plasma levels. | Huber, S., et al. 1992. Amino Acids. 2: 225-32. PMID: 24192901
- Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor. | Kolesnikov, YA., et al. 1993. Proc Natl Acad Sci U S A. 90: 5162-6. PMID: 7685116
- NO- and NO2-carrying molecules potentiate photorelaxation in rat trachea and aorta. | Chang, KC., et al. 1993. Biochem Biophys Res Commun. 191: 509-14. PMID: 8461007
- Preventive effect of N(G)-nitro-L-arginine against L-cysteine-induced seizures in mice. | Yamamoto, H. 1996. Toxicol Lett. 84: 1-5. PMID: 8597172
- N(G)-nitro-L-arginine reverses L-arginine induced changes in morphine antinociception and distribution of morphine in brain regions and spinal cord of the mouse. | Bhargava, HN. and Bian, JT. 1997. Brain Res. 749: 351-3. PMID: 9138738
Inhibitor of:
NOS1, NOS2, and NOS3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N G-Nitro-L-arginine, 1 g | sc-3570 | 1 g | $19.00 |