Molecular structure of N-Formyl-Met-Leu-Phe, CAS Number: 59880-97-6
N-Formyl-Met-Leu-Phe (CAS 59880-97-6)
Alternate Names:
Formyl-Met-Leu-Phe-OH; Chemotactic Peptide
Application:
N-Formyl-Met-Leu-Phe is an inducer of superoxide release and agonist for FPR1
CAS Number:
59880-97-6
Purity:
≥97%
Molecular Weight:
437.55
Molecular Formula:
C21H31N3O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Formyl-Met-Leu-Phe is an endogenous chemotactic peptide for polymorphonuclear leukocyte and may act to stimulate aggregation of leukocytes. N-Formyl-Met-Leu-Phe induces superoxide release from neutrophils. N-Formyl-Met-Leu-Phe is also an agonist for the FPR (formyl peptide receptor 1) (Ki = 38 nM).
N-Formyl-Met-Leu-Phe (CAS 59880-97-6) References
- Phe-D-Leu-Phe-D-Leu-Phe derivatives as formylpeptide receptor antagonists in human neutrophils: cellular and conformational aspects. | Dalpiaz, A., et al. 1999. Biochim Biophys Acta. 1432: 27-39. PMID: 10366725
- The bacterial peptide N-formyl-Met-Leu-Phe inhibits killing of Staphylococcus epidermidis by human neutrophils in fibrin gels. | Li, Y., et al. 2002. J Immunol. 168: 816-24. PMID: 11777977
- Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis. | Hannigan, M., et al. 2002. Proc Natl Acad Sci U S A. 99: 3603-8. PMID: 11904423
- N-formyl-Met-Leu-Phe-induced oxidative burst in DMSO-differentiated HL-60 cells requires active Hsp90, but not intact microtubules. | Vrba, J. and Modrianský, M. 2004. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 148: 141-4. PMID: 15744362
- Temperature pretreatment alters the polarization response of human neutrophils to the chemoattractant N-formyl-Met-Leu-Phe. | Zhao, D., et al. 2009. Inflammation. 32: 47-56. PMID: 19067145
- Commensal-epithelial signaling mediated via formyl peptide receptors. | Wentworth, CC., et al. 2010. Am J Pathol. 177: 2782-90. PMID: 21037077
- Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids. | Colucci, M., et al. 2011. Peptides. 32: 266-71. PMID: 21126546
- Histamine and sulfidoleukotriene release from human basophils: different effects of antigen, anti-IgE, C5a, f-Met-Leu-Phe and the novel neutrophil-activating peptide NAF. | Dahinden, CA., et al. 1989. Int Arch Allergy Appl Immunol. 90: 113-8. PMID: 2479603
- Phospholipase A2 activation in human neutrophils. Differential actions of diacylglycerols and alkylacylglycerols in priming cells for stimulation by N-formyl-Met-Leu-Phe. | Bauldry, SA., et al. 1988. J Biol Chem. 263: 16787-95. PMID: 2846550
- Lipopeptide PAM3CYS4 Synergizes N-Formyl-Met-Leu-Phe (fMLP)-Induced Calcium Transients in Mouse Neutrophils. | Ding, R., et al. 2018. Shock. 50: 493-499. PMID: 29176405
- Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin. | Lad, PM., et al. 1985. Proc Natl Acad Sci U S A. 82: 869-73. PMID: 2983319
- Inhibition of human neutrophil receptor-mediated uptake of N-formyl-met-leu-phe by platelet factor 4 (59-70). | Goldman, DW., et al. 1985. Immunology. 54: 163-72. PMID: 3838292
- Arachidonate metabolism by human polymorphonuclear leukocytes stimulated by N-formyl-Met-Leu-Phe or complement component C5a is independent of phospholipase activation. | Clancy, RM., et al. 1983. Proc Natl Acad Sci U S A. 80: 7200-4. PMID: 6417666
- Acute ethanol intoxication regulates f-met-leu-phe-induced chemotaxis and superoxide release by neutrophils and Kupffer cells through modulation of the formyl peptide receptor in the rat. | Bautista, AP. and Elliott, KE. 1994. Life Sci. 54: 721-30. PMID: 8107522
- Flow cytometric investigation of neutrophil activation pathways by n-formyl-Met-Leu-Phe and phorbol myristate acetate. | Zhang, J., et al. 1995. Biol Cell. 84: 147-53. PMID: 8720435
Inhibitor of:
FPR.Activator of:
FPR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Formyl-Met-Leu-Phe, 5 mg | sc-358988 | 5 mg | $44.00 | |||
N-Formyl-Met-Leu-Phe, 10 mg | sc-358988A | 10 mg | $59.00 |