N-Desmethylclozapine (CAS 6104-71-8)
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N-Desmethylclozapine is utilized in neuropsychopharmacology research to explore its impact on neurotransmitter systems, particularly focusing on its role as a serotonin and dopamine modulator. This compound is of interest due to its ability to act as a partial agonist at the serotonin 5-HT1A receptor, and research often investigates its effects on neurotransmitter release and receptor dynamics. N-Desmethylclozapine is also studied for its influence on dopamine pathways, which are integral to understanding a variety of neurological conditions. The chemical′s action on these critical neurotransmitter systems provides valuable insights into the mechanisms of neuromodulation and its potential implications for brain function and behavior. Additionally, N-Desmethylclozapine is used in studies related to synaptic transmission, aiding in the broader understanding of synaptic mechanisms within the central nervous system.
N-Desmethylclozapine (CAS 6104-71-8) References
- Determination of clozapine, and its metabolites, N-desmethylclozapine and clozapine N-oxide in dog plasma using high-performance liquid chromatography. | Mosier, KE., et al. 2003. J Chromatogr B Analyt Technol Biomed Life Sci. 783: 377-82. PMID: 12482480
- N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. | Sur, C., et al. 2003. Proc Natl Acad Sci U S A. 100: 13674-9. PMID: 14595031
- The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions? | Davies, MA., et al. 2005. Psychopharmacology (Berl). 178: 451-60. PMID: 15765260
- N-desmethylclozapine an M1 receptor agonist enhances nitric oxide's cardiac vagal facilitation in the isolated innervated rat right atrium. | Hogan, K., et al. 2007. Auton Neurosci. 137: 51-5. PMID: 17702668
- N-Desmethylclozapine exerts dual and opposite effects on salivary secretion in the rat. | Ekström, J., et al. 2010. Eur J Oral Sci. 118: 1-8. PMID: 20156258
- N-desmethylclozapine (NDMC) is an antagonist at the human native muscarinic M(1) receptor. | Thomas, DR., et al. 2010. Neuropharmacology. 58: 1206-14. PMID: 20206188
- Ameliorative effect of N-desmethylclozapine in animal models of social deficits and cognitive functions. | Maehara, S., et al. 2011. Brain Res Bull. 86: 146-51. PMID: 21855612
- Behavioral effects of N-desmethylclozapine on locomotor activity and sensorimotor gating function in mice-Possible involvement of muscarinic receptors. | Maehara, S., et al. 2011. Brain Res. 1418: 111-9. PMID: 21917240
- Discriminative stimulus properties of N-desmethylclozapine, the major active metabolite of the atypical antipsychotic clozapine, in C57BL/6 mice. | Wiebelhaus, JM., et al. 2012. Behav Pharmacol. 23: 262-70. PMID: 22547022
- Microdialysis evaluation of clozapine and N-desmethylclozapine pharmacokinetics in rat brain. | Cremers, TI., et al. 2012. Drug Metab Dispos. 40: 1909-16. PMID: 22736307
- Impact of clozapine, N-desmethylclozapine and chlorpromazine on thromboxane production in vitro. | Himmerich, H., et al. 2012. Med Chem. 8: 1032-8. PMID: 22757658
- Longitudinal effects of clozapine concentration and clozapine to N-desmethylclozapine ratio on cognition: A mediation model. | Dal Santo, F., et al. 2020. Eur Neuropsychopharmacol. 33: 158-163. PMID: 32057590
- Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists. | Kuoppamäki, M., et al. 1993. Eur J Pharmacol. 245: 179-82. PMID: 8387927
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Desmethylclozapine, 5 mg | sc-201113 | 5 mg | $98.00 | |||
N-Desmethylclozapine, 25 mg | sc-201113A | 25 mg | $364.00 |