N-Desmethyl Tadalafil (CAS 171596-36-4)
Alternate Names:
(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1,2:1,6]pyrido[3,4-b]indole-1,4-dione; (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1,2:1,6]pyrido[3,4-b]indole-1,4-dione; Nortadalafil
CAS Number:
171596-36-4
Molecular Weight:
375.38
Molecular Formula:
C21H17N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Desmethyl Tadalafil is a chemical compound recognized for its role within the realm of phosphodiesterase type 5 (PDE5) inhibitors, serving as a structural analog of tadalafil and distinguished by its mechanism of action that centers on the inhibition of PDE5 enzyme activity. This enzyme is pivotal in the degradation process of cyclic guanosine monophosphate (cGMP), a cellular messenger. The inhibition of PDE5 by N-Desmethyl Tadalafil results in an elevation of cGMP levels within the system, which in turn, facilitates the relaxation of smooth muscle cells.
N-Desmethyl Tadalafil (CAS 171596-36-4) References
- Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics. | Tyagi, R., et al. 2019. Sci Rep. 9: 9085. PMID: 31235822
- Improved molecular softness of tadalafil hapten enhancing antibody performance in immunoassay: Evidence from computational chemistry. | Yang, JY., et al. 2022. J Food Sci. 87: 1342-1354. PMID: 35166370
- Detection of Tadalafil and Its Analogues in Health Wine and Oral Liquid by Microwell Lateral Flow Immunochromatography Assay | ZOU Ting-Ting a, YANG Jin-Yi a, XU Zhen-Lin a, WANG Hong a, SUN Yuan-Ming a, LEI Hong-Tao a, TAN Xue-Cai b, SHEN Yu-Dong a. 2019. Chinese Journal of Analytical Chemistry. 47: 1249-1257.
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Desmethyl Tadalafil, 5 mg | sc-500690 | 5 mg | $398.00 |