Molecular structure of N-Desmethyl Sildenafil-d8, CAS Number: 1185168-06-2
N-Desmethyl Sildenafil-d8 (CAS 1185168-06-2)
Application:
N-Desmethyl Sildenafil-d8 is a deuterium-labelled analog of Sildenafil
CAS Number:
1185168-06-2
Molecular Weight:
468.60
Molecular Formula:
C21H20D8N6O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Desmethyl Sildenafil-d8 is a deuterium-labelled analog of Sildenafil (sc-338584). Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.
N-Desmethyl Sildenafil-d8 (CAS 1185168-06-2) References
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- Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism. | Kato, N., et al. 2009. Dig Dis Sci. 54: 2346-56. PMID: 19101800
- Development and validation of an ultra performance liquid chromatography tandem mass method for sildenafil and N-desmethyl sildenafil plasma determination and quantification. | Simiele, M., et al. 2015. J Chromatogr B Analyt Technol Biomed Life Sci. 1001: 35-40. PMID: 26253809
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- UPLC-MS/MS for the Simultaneous Determination of Sildenafil and N-Desmethyl Sildenafil. | Zhu, WL., et al. 2021. J Chromatogr Sci. 59: 823-829. PMID: 33517421
- Sildenafil and N-desmethyl sildenafil quantification in human plasma by HPLC coupled with ESI-MS/MS detection: Application to bioequivalence study | Challa, B. R., Awen, B. Z., Chandu, B. R., Khagga, M., Bannoth, C. K., Kanala, K.,.. & Gogineni, R. 2010. Analytical Methods. 2(8): 1043-1050.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Desmethyl Sildenafil-d8, 1 mg | sc-219131 | 1 mg | $250.00 |