N-Desmethyl Clomipramine Hydrochloride (CAS 29854-14-6)
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N-Desmethyl Clomipramine Hydrochloride (DCMH) is an important component derived from clomipramine, It serves as a significant metabolite. It has proven valuable in investigating the mechanisms of action of serotonin reuptake inhibitors and their impact on serotonin levels within the brain. The primary function of N-Desmethyl Clomipramine Hydrochloride lies in its potent inhibition of serotonin reuptake. This mechanism blocks the reuptake of serotonin from the synaptic cleft, leading to increased serotonin availability for the postsynaptic neuron. This activity is believed to underlie the antidepressant effects of N-Desmethyl Clomipramine Hydrochloride. Additionally, it is thought to act as an antagonist at specific serotonin receptors, further elevating serotonin levels in the brain.
N-Desmethyl Clomipramine Hydrochloride (CAS 29854-14-6) References
- Effects of 31 recombinant CYP2C19 variants on clomipramine metabolism in vitro. | Lan, T., et al. 2021. J Psychopharmacol. 35: 1517-1522. PMID: 34702100
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Desmethyl Clomipramine Hydrochloride, 2.5 mg | sc-212183 | 2.5 mg | $360.00 |