N-Decanoyl-N-methylglucamine (CAS 85261-20-7)

N-Decanoyl-N-methylglucamine, commonly known as MEGA-10, is a non-ionic detergent widely utilized in scientific research due to its unique properties and versatile applications. Its mechanism of action involves disrupting lipid-lipid and lipid-protein interactions within biological membranes, effectively solubilizing membrane proteins while maintaining their native structure and function. In research, MEGA-10 is extensively employed in various biochemical and biophysical techniques, including protein purification, membrane protein extraction, and structural biology studies. Its ability to solubilize membrane proteins without denaturation makes it particularly valuable in preserving the native conformation of integral membrane proteins during isolation and purification processes. Additionally, MEGA-10 finds applications in lipidomics research for solubilizing lipids and in lipid bilayer studies for stabilizing lipid vesicles for biophysical assays. Ongoing research continues to explore novel uses and formulations of MEGA-10, highlighting its significance as a crucial tool in elucidating membrane biology, protein-lipid interactions, and the structural and functional properties of biomolecules.