Molecular structure of N-Deacetylcolchiceine, CAS Number: 3482-37-9
N-Deacetylcolchiceine (CAS 3482-37-9)
Alternate Names:
(7S)-7-Amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-benzo[a]heptalen-9(5H)-one
CAS Number:
3482-37-9
Molecular Weight:
343.37
Molecular Formula:
C19H21NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Antimitotic agent disrupting microtubule action through the binding of tubulin and preventing polymerization. Has been shown to stimulate the intrinsic GTPase activity of tubulin. Induces apoptosis and activates the JNK/SAPK signals.
N-Deacetylcolchiceine (CAS 3482-37-9) References
- Effect of colchicine and its derivatives on the expression of selected isoforms of cytochrome P450 in primary cultures of human hepatocytes. | Dvorák, Z., et al. 2000. Acta Univ Palacki Olomuc Fac Med. 143: 47-50. PMID: 11144118
- Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants? | Modriansky, M., et al. 2002. Toxicology. 177: 105-17. PMID: 12126799
- Tubulin structure and biochemistry. | Ludueña, RF., et al. 1992. Curr Opin Cell Biol. 4: 53-7. PMID: 1558754
- The effect of N-deacetylcolchiceine on serum lipoproteins in rats. | Skottová, N., et al. 1992. Planta Med. 58: 26-30. PMID: 1620740
- Behavior of drug excited states within macromolecules: binding of colchicine and derivatives to albumin. | Bosca, F. and Tormos, R. 2013. J Phys Chem B. 117: 7528-34. PMID: 23730875
- Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. | Ceccatelli, S., et al. 1997. Neuroreport. 8: 3779-83. PMID: 9427370
- Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. | Wang, TH., et al. 1998. J Biol Chem. 273: 4928-36. PMID: 9478937
- Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. | Andreu, JM., et al. 1998. Biochemistry. 37: 8356-68. PMID: 9622487
- Simple conversion of colchicine into demecolcine | Capraro, H. G., & Brossi, A. 1979. Helvetica Chimica Acta. 62(4): 965-970.
- The reasons for fluorescence emitting from the mixture of colchicine and H2SO4 | Hui, W., Leilei, L., Shuqin, L., & Yu, W. 2005. Analytical letters. 38(12): 1967-1973.
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Deacetylcolchiceine, 100 mg | sc-208016 | 100 mg | $345.00 |