Date published: 2026-4-5

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N-Chlorosuccinimide (CAS 128-09-6)

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Application:
N-Chlorosuccinimide is A regioselective chlorination and oxidizing reagent
CAS Number:
128-09-6
Molecular Weight:
133.53
Molecular Formula:
C4H4ClNO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-Chlorosuccinimide is a regioselective chlorination and oxidizing reagent. N-Chlorosuccinimide (NCS) is a widely used chemical reagent in the fields of synthetic organic chemistry and biochemistry. It plays a role as an intermediate in the synthesis of diverse compounds, including dyes and agrochemicals. Moreover, N-Chlorosuccinimide is highly valuable for creating N-chloro compounds, which find applications in various areas. Beyond its significance in scientific research, N-Chlorosuccinimide holds versatility as a reagent in a multitude of synthetic reactions. When N-Chlorosuccinimide interacts with organic substrates, it forms N-chloro compounds through a reaction initiated by the generation of a chlorinating agent. This chlorinating agent originates from the reaction between N-Chlorosuccinimide and a base, leading to the formation of the desired N-chloro compound. N-Chlorosuccinimide stands as a reagent with wide-ranging utility in both synthetic organic chemistry and biochemistry. Its diverse applications encompass the synthesis of various compounds and its role in the formation of essential N-chloro compounds, making it an indispensable tool for scientific exploration and innovation.


N-Chlorosuccinimide (CAS 128-09-6) References

  1. Synthesis of sulfonimidamides from sulfinamides by oxidation with N-chlorosuccinimide.  |  Mancheño, OG. and Bolm, C. 2007. Beilstein J Org Chem. 3: 25. PMID: 17894869
  2. Flow injection chemiluminescence determination of sulfide by oxidation with N-bromosuccinimide and N-chlorosuccinimide.  |  Safavi, A. and Karimi, MA. 2002. Talanta. 57: 491-500. PMID: 18968648
  3. N-Chlorosuccinimide, an efficient reagent for on-resin disulfide formation in solid-phase peptide synthesis.  |  Postma, TM. and Albericio, F. 2013. Org Lett. 15: 616-9. PMID: 23320397
  4. Flow-injection chemiluminescence determination of olanzapine using N-chlorosuccinimide-calcein reaction sensitized by zinc (II).  |  Zhao, F., et al. 2014. Luminescence. 29: 219-24. PMID: 23723137
  5. Immobilized N-chlorosuccinimide as a friendly peptide disulfide-forming reagent.  |  Postma, TM. and Albericio, F. 2014. ACS Comb Sci. 16: 160-3. PMID: 24641490
  6. N-chlorosuccinimide-promoted regioselective sulfenylation of imidazoheterocycles at room temperature.  |  Ravi, C., et al. 2014. Org Lett. 16: 2978-81. PMID: 24838116
  7. N-Chlorosuccinimide-mediated oxidative chlorination of thiols to Nα-protected amino alkyl sulfonyl azides and their utility in the synthesis of sulfonyl triazole acids.  |  Sharnabai, KM., et al. 2016. Protein Pept Lett.. PMID: 27908261
  8. Synthesis of Azobenzenes Using N-Chlorosuccinimide and 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU).  |  Antoine John, A. and Lin, Q. 2017. J Org Chem. 82: 9873-9876. PMID: 28846399
  9. N-Hydroxyphthalimide/benzoquinone-catalyzed chlorination of hydrocarbon C-H bond using N-chlorosuccinimide.  |  Li, ZH., et al. 2019. Org Biomol Chem. 17: 3403-3408. PMID: 30869109
  10. One-Pot Synthesis of P(O)-N Containing Compounds Using N-Chlorosuccinimide and Their Influence in Thermal Decomposition of PU Foams.  |  Salmeia, KA., et al. 2018. Polymers (Basel). 10: PMID: 30960665
  11. Visible-light-induced C(sp3)-H functionalizations of piperidines to 3,3-dichloro-2-hydroxy-piperidines with N-chlorosuccinimide.  |  Wang, F., et al. 2021. Org Biomol Chem. 19: 6141-6146. PMID: 34180488
  12. A Mechanistic Study for Aziridination of Nitroalkenes Mediated by N-Chlorosuccinimide.  |  Iwai, K., et al. 2022. J Oleo Sci. 71: 897-903. PMID: 35584955
  13. N-chlorosuccinimide enhancing the antimicrobial effect of benzalkonium chloride on biofilm Pseudomonas aeruginosa and its interaction mechanisms.  |  Huang, Z., et al. 2022. J Environ Sci Health A Tox Hazard Subst Environ Eng. 1-8. PMID: 35852222

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Chlorosuccinimide, 100 g

sc-250458
100 g
$24.00