Molecular structure of N-butyryl-L-Homoserine lactone, CAS Number: 67605-85-0
N-butyryl-L-Homoserine lactone (CAS 67605-85-0)
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Alternate Names:
C4-HSL; N-Butyryl-L-homoserine lactone
Application:
N-butyryl-L-Homoserine lactone is a diffusable quorum sensing lactone
CAS Number:
67605-85-0
Purity:
≥95%
Molecular Weight:
171.2
Molecular Formula:
C8H13NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-butyryl-L-Homoserine lactone, quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-butyryl-L-Homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this molecule include regulation of virulence in general, infection prevention, and formation of biofilms.
N-butyryl-L-Homoserine lactone (CAS 67605-85-0) References
- The Pseudomonas aeruginosa autoinducer N-3-oxododecanoyl homoserine lactone accelerates apoptosis in macrophages and neutrophils. | Tateda, K., et al. 2003. Infect Immun. 71: 5785-93. PMID: 14500500
- [Negative regulation on PCA production is not correlated with positive regulation on BHL and HHL synthesis by gacA in Pseudomonas sp. M18]. | Tang, XY., et al. 2006. Wei Sheng Wu Xue Bao. 46: 478-81. PMID: 16933626
- Directed evolution of a thermostable quorum-quenching lactonase from the amidohydrolase superfamily. | Chow, JY., et al. 2010. J Biol Chem. 285: 40911-20. PMID: 20980257
- Acylase-containing polyurethane coatings with anti-biofilm activity. | Grover, N., et al. 2016. Biotechnol Bioeng. 113: 2535-2543. PMID: 27240552
- Control of quorum sensing and virulence factors of Pseudomonas aeruginosa using phenylalanine arginyl β-naphthylamide. | El-Shaer, S., et al. 2016. J Med Microbiol. 65: 1194-1204. PMID: 27498852
- Characterization of syntrophic Geobacter communities using ToF-SIMS. | Wei, W., et al. 2017. Biointerphases. 12: 05G601. PMID: 28821212
- Aii810, a Novel Cold-Adapted N-Acylhomoserine Lactonase Discovered in a Metagenome, Can Strongly Attenuate Pseudomonas aeruginosa Virulence Factors and Biofilm Formation. | Fan, X., et al. 2017. Front Microbiol. 8: 1950. PMID: 29067011
- Pseudomonas aeruginosa quorum sensing molecule N-3-oxo-dodecanoyl-l-homoserine lactone activates human platelets through intracellular calcium-mediated ROS generation. | Yadav, VK., et al. 2018. Int J Med Microbiol. 308: 858-864. PMID: 30098883
- Preliminary study testing the effects of tea and coffee on sludge characteristics and N-butyryl-l-homoserine lactone in an MBR system. | Turan, NB., et al. 2020. Environ Technol. 41: 2085-2095. PMID: 30513046
- Autoinducer N-(3-oxododecanoyl)-l-homoserine lactone induces calcium and reactive oxygen species-mediated mitochondrial damage and apoptosis in blood platelets. | Yadav, VK., et al. 2021. Microb Pathog. 154: 104792. PMID: 33636321
- Short-chain reactive probes as tools to unravel the Pseudomonas aeruginosa quorum sensing regulon. | Yashkin, A., et al. 2021. Chem Sci. 12: 4570-4581. PMID: 34163722
- Insight of the bio-cathode biofilm construction in microbial electrolysis cell dealing with sulfate-containing wastewater. | Shi, K., et al. 2022. Bioresour Technol. 361: 127695. PMID: 35905879
- Impact of N-butyryl-l-homoserine lactone-mediated quorum sensing on acidogenic fermentation under saline conditions: Insights into volatile fatty acids production and microbial community. | Chen, Y., et al. 2023. Bioresour Technol. 368: 128354. PMID: 36410593
- The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase. | Reimmann, C., et al. 1997. Mol Microbiol. 24: 309-19. PMID: 9159518
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-butyryl-L-Homoserine lactone, 5 mg | sc-205402 | 5 mg | $46.00 | |||
N-butyryl-L-Homoserine lactone, 10 mg | sc-205402A | 10 mg | $87.00 |