Molecular structure of N-Butyl-N-(4-hydroxybutyl)nitrosamine, CAS Number: 3817-11-6
N-Butyl-N-(4-hydroxybutyl)nitrosamine (CAS 3817-11-6)
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CAS Number:
3817-11-6
Molecular Weight:
174.24
Molecular Formula:
C8H18N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN) is a compound classified as a nitrosamine, extensively employed in diverse scientific research endeavors. Its physical properties include being a colorless and volatile liquid. The mechanism of action for N-Butyl-N-(4-hydroxybutyl)nitrosamine entails its metabolism within the body, resulting in the formation of reactive metabolites. These metabolites possess the capability to interact with DNA, proteins, and enzymes. Consequently, they induce biochemical and physiological alterations, leading to a wide range of effects.
N-Butyl-N-(4-hydroxybutyl)nitrosamine (CAS 3817-11-6) References
- Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis. | Murai, T., et al. 2005. Cancer Sci. 96: 637-44. PMID: 16232194
- Dietary beta-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice. | Miyazawa, K., et al. 2007. Oncol Rep. 17: 297-304. PMID: 17203164
- Tissue-specific mutagenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine as the basis for urothelial carcinogenesis. | He, Z., et al. 2012. Mutat Res. 742: 92-5. PMID: 22155125
- Cytogenetic characterization of an N-butyl-N-(4-hydroxybutyl) nitrosamine-induced mouse papillary urothelial carcinoma. | Arantes-Rodrigues, R., et al. 2013. Tumour Biol. 34: 2691-6. PMID: 23645214
- Antiproliferative and anti-inflammatory properties of diindolylmethane and lupeol against N-butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis in experimental rats. | Prabhu, B., et al. 2016. Hum Exp Toxicol. 35: 685-92. PMID: 26251508
- Knockout of phospholipase Cε attenuates N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder tumorigenesis. | Jiang, T., et al. 2016. Mol Med Rep. 13: 2039-45. PMID: 26782701
- DNA cytophotometric and histological analysis of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced precancerous lesions of the bladder urothelium. | Dahm, HH., et al. 2016. J Cancer Res Clin Oncol. 142: 1253-60. PMID: 27033373
- The N-butyl-N-4-hydroxybutyl Nitrosamine Mouse Urinary Bladder Cancer Model. | Oliveira, PA., et al. 2018. Methods Mol Biol. 1655: 155-167. PMID: 28889385
- The interaction of arsenic and N-butyl-N-(4-hydroxybutyl)nitrosamine on urothelial carcinogenesis in mice. | Dai, YC., et al. 2017. PLoS One. 12: e0186214. PMID: 29016672
- Strain differences in N-butyl-N-(4-hydroxybutyl)nitrosamine bladder carcinogenesis in rats. | Nakanowatari, J., et al. 1988. Jpn J Cancer Res. 79: 453-9. PMID: 3133335
- Promotion effects of acetoaceto-o-toluidide on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder carcinogenesis in rats. | Yukimatsu, N., et al. 2019. Arch Toxicol. 93: 3617-3631. PMID: 31673724
- Persistent γ-H2AX Formation and Expression of Stem Cell Markers in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Bladder Carcinogenesis in Rats. | Yamada, T., et al. 2022. Toxicol Sci. 189: 51-61. PMID: 35771629
- Frequent p53 mutations and occasional loss of chromosome 4 in invasive bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in B6D2F1 mice. | Ogawa, K., et al. 1998. Mol Carcinog. 21: 70-9. PMID: 9473773
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Butyl-N-(4-hydroxybutyl)nitrosamine, 5 g | sc-486264 | 5 g | $265.00 | |||
N-Butyl-N-(4-hydroxybutyl)nitrosamine, 25 g | sc-486264A | 25 g | $866.00 |