Molecular structure of N-Arachidonoyl-serotonin, CAS Number: 187947-37-1
N-Arachidonoyl-serotonin (CAS 187947-37-1)
Application:
N-Arachidonoyl-serotonin is a selective FAAH and TRPV1 channel inhibitor
CAS Number:
187947-37-1
Purity:
98%
Molecular Weight:
462.7
Molecular Formula:
C30H42N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Arachidonoyl-serotonin is a selective FAAH (fatty acid amid hydrolase) and VR1 (transient receptor potential vanilloid-1, TRPV1) channel inhibitor. TRPV1 is a Capsaicin (sc-3577) receptor, which behaves as a non-selective cation channel and are mainly found in the sensory neurons that detect painful stimuli. The compound may act to be inactive against cPLA2 and CB1. Rat brain studies suggests that N-Arachidonoyl-serotonin acts as an enhancer of endocannabinoid levels, and increases the levels of anadamide and 2-AG (sc-200794).
N-Arachidonoyl-serotonin (CAS 187947-37-1) References
- Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels. | de Lago, E., et al. 2005. Biochem Pharmacol. 70: 446-52. PMID: 15963472
- Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. | Maione, S., et al. 2007. Br J Pharmacol. 150: 766-81. PMID: 17279090
- The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats. | de Novellis, V., et al. 2008. Neuropharmacology. 55: 1105-13. PMID: 18616956
- The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice. | Costa, B., et al. 2010. Pharmacol Res. 61: 537-46. PMID: 20138997
- TRPV1 splice variants: structure and function. | Schumacher, MA. and Eilers, H. 2010. Front Biosci (Landmark Ed). 15: 872-82. PMID: 20515731
- N-arachidonoyl-serotonin in the basolateral amygdala increases anxiolytic behavior in the elevated plus maze. | John, CS. and Currie, PJ. 2012. Behav Brain Res. 233: 382-8. PMID: 22633963
- Anticonvulsant effects of N-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (TRPV1) channel blocker, on experimental seizures: the roles of cannabinoid CB1 receptors and TRPV1 channels. | Vilela, LR., et al. 2014. Basic Clin Pharmacol Toxicol. 115: 330-4. PMID: 24674273
- Anti-Inflammatory and Antioxidant Actions of N-Arachidonoyl Serotonin in RAW264.7 Cells. | Jeon, HL., et al. 2016. Pharmacology. 97: 195-206. PMID: 26859139
- N-arachidonoyl-serotonin, a dual FAAH and TRPV1 blocker, inhibits the retrieval of contextual fear memory: Role of the cannabinoid CB1 receptor in the dorsal hippocampus. | Gobira, PH., et al. 2017. J Psychopharmacol. 31: 750-756. PMID: 28583049
- Role of N-Arachidonoyl-Serotonin (AA-5-HT) in Sleep-Wake Cycle Architecture, Sleep Homeostasis, and Neurotransmitters Regulation. | Murillo-Rodríguez, E., et al. 2017. Front Mol Neurosci. 10: 152. PMID: 28611585
- Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT). | Bashashati, M., et al. 2017. Neurogastroenterol Motil. 29: PMID: 28695708
- Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel. | Arnold, WR., et al. 2021. Nat Commun. 12: 926. PMID: 33568652
- Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. | Bisogno, T., et al. 1998. Biochem Biophys Res Commun. 248: 515-22. PMID: 9703957
Inhibitor of:
FAAH, and VR1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Arachidonoyl-serotonin, 10 mg | sc-201460 | 10 mg | $80.00 | |||
N-Arachidonoyl-serotonin, 50 mg | sc-201460A | 50 mg | $268.00 |