Molecular structure of N-Acetyltryptamine, CAS Number: 1016-47-3
N-Acetyltryptamine (CAS 1016-47-3)
Alternate Names:
3-(2-N-Acetylaminoethyl)indole
Application:
N-Acetyltryptamine is a partial agonist for melatonin receptors in the retina
CAS Number:
1016-47-3
Molecular Weight:
202.25
Molecular Formula:
C12H14N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Acetyltryptamine is a partial agonist of the MEL-1 (melatonin receptors). N-Acetyltryptamine bears a reduced structure of Melatonin (sc-207848), lacking the 5-methoxy group. N-Acetyltryptamine is described to demonstrate agonism at melatonin receptors in the rabbit retina, inhibiting Ca2+-dependent release of [3H]dopamine. N-Acetyltryptamine is also described to demonstrate competitive antagonism of the inhibitory effect of melatonin on [3H]dopamine release in the chicken retina.
N-Acetyltryptamine (CAS 1016-47-3) References
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- Molecular cloning of rice serotonin N-acetyltransferase, the penultimate gene in plant melatonin biosynthesis. | Kang, K., et al. 2013. J Pineal Res. 55: 7-13. PMID: 22998587
- Luzindole (N-0774): a novel melatonin receptor antagonist. | Dubocovich, ML. 1988. J Pharmacol Exp Ther. 246: 902-10. PMID: 2843633
- Characterization of a retinal melatonin receptor. | Dubocovich, ML. 1985. J Pharmacol Exp Ther. 234: 395-401. PMID: 2991499
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- Distribution and metabolism of tryptamine in rat brain. | Wu, PH. and Boulton, AA. 1973. Can J Biochem. 51: 1104-12. PMID: 4725358
- Melatonin receptor-mediated inhibition of cyclic AMP accumulation in chick retinal cell cultures. | Iuvone, PM. and Gan, J. 1994. J Neurochem. 63: 118-24. PMID: 7515941
- Pharmacologic characterization of melatonin-mediated phosphoinositide hydrolysis in pigeon brain. | Mullins, UL. and Eison, AS. 1994. J Pineal Res. 17: 33-8. PMID: 7853142
- Thermodynamic analysis of agonist and antagonist binding to the chicken brain melatonin receptor. | Chong, NW. and Sugden, D. 1994. Br J Pharmacol. 111: 295-301. PMID: 8012710
- Melatonin binding sites are functionally coupled to phosphoinositide hydrolysis in Syrian hamster RPMI 1846 melanoma cells. | Eison, AS. and Mullins, UL. 1993. Life Sci. 53: PL393-8. PMID: 8246675
- Circadian clock controlling arylalkylamine N-acetyltransferase-like activity in the cricket (Gryllus bimaculatus) egg. | Itoh, MT. and Sumi, Y. 1998. Brain Res. 799: 172-5. PMID: 9666117
Activator of:
MEL-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Acetyltryptamine, 10 mg | sc-202233 | 10 mg | $117.00 | |||
N-Acetyltryptamine, 50 mg | sc-202233A | 50 mg | $495.00 |