Molecular structure of N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC), CAS Number: 139332-94-8
N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) (CAS 139332-94-8)
See product citations (2)
Application:
N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) is a methyltransferase substrate
CAS Number:
139332-94-8
Purity:
≥98%
Molecular Weight:
435.7
Molecular Formula:
C25H41NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) is a substrate for the carboxyl methyltransferase that is shown to inhibit Ras carboxyl methylation. The Ras subfamily is usually responsible for cell proliferation and inhibition of it will cause a halt in cell division. This compound has been noted to also be a competitive inhibitor for prenylcysteine methyl transferase which doubles the rate of basal and stimulates insulin secretion in a reversible and ATP-dependent manner. Additionally, this agent has been found to inhibit Integrin β2-induced actin polymerization in neutrophils.
N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) (CAS 139332-94-8) References
- Isoprenylcysteine carboxyl methyltransferase deficiency in mice. | Bergo, MO., et al. 2001. J Biol Chem. 276: 5841-5. PMID: 11121396
- Carboxyl-methylation of Rab3D in the rat pancreatic acinar tumor cell line AR42J. | Qiu, X., et al. 2001. Biochem Biophys Res Commun. 285: 708-14. PMID: 11453651
- Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells. | Ahmad, M., et al. 2002. Arterioscler Thromb Vasc Biol. 22: 759-64. PMID: 12006387
- Activation of Rac2 and Cdc42 on Fc and complement receptor ligation in human neutrophils. | Forsberg, M., et al. 2003. J Leukoc Biol. 74: 611-9. PMID: 12960248
- Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation. | Lu, Q., et al. 2004. Circ Res. 94: 306-15. PMID: 14699010
- Purification, functional reconstitution, and characterization of the Saccharomyces cerevisiae isoprenylcysteine carboxylmethyltransferase Ste14p. | Anderson, JL., et al. 2005. J Biol Chem. 280: 7336-45. PMID: 15611058
- A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues. | Volker, C., et al. 1991. FEBS Lett. 295: 189-94. PMID: 1765152
- Pulmonary endothelial cell signaling and function. | Rounds, S., et al. 2008. Trans Am Clin Climatol Assoc. 119: 155-67; discussion 167-9. PMID: 18596849
- An insect farnesyl phosphatase homologous to the N-terminal domain of soluble epoxide hydrolase. | Cao, L., et al. 2009. Biochem Biophys Res Commun. 380: 188-92. PMID: 19168029
- Macrolide antibiotics inhibit respiratory syncytial virus infection in human airway epithelial cells. | Asada, M., et al. 2009. Antiviral Res. 83: 191-200. PMID: 19463856
- Prenylcysteine analogs mimicking the C-terminus of GTP-binding proteins stimulate exocytosis from permeabilized HIT-T15 cells: comparison with the effect of Rab3AL peptide. | Regazzi, R., et al. 1995. Biochim Biophys Acta. 1268: 269-78. PMID: 7548225
- Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils. | Philips, MR., et al. 1993. Science. 259: 977-80. PMID: 8438158
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC), 5 mg | sc-200843 | 5 mg | $90.00 | |||
N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC), 25 mg | sc-200843A | 25 mg | $349.00 |