N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) is a substrate for the carboxyl methyltransferase that is shown to inhibit Ras carboxyl methylation. The Ras subfamily is usually responsible for cell proliferation and inhibition of it will cause a halt in cell division. This compound has been noted to also be a competitive inhibitor for prenylcysteine methyl transferase which doubles the rate of basal and stimulates insulin secretion in a reversible and ATP-dependent manner. Additionally, this agent has been found to inhibit Integrin β2-induced actin polymerization in neutrophils.
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See how others have used N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC). Click on the entry to view the PubMed entry .
PMID: # 27710830 Zhao, Y. et al. 2016. Eur. J. Cancer. 68: 38-50.
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