N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (mixture of diastereomers) (CAS 144889-50-9)
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N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (mixture of diastereomers) is particularly valued for its role as a metabolite analog and its potential in detoxification studies. It mimics the structure of certain metabolites, allowing researchers to investigate pathways involved in the metabolism of fatty acids and toxins. The compound′s ability to form conjugates with various xenobiotics or endogenous toxins through its thiol group makes it a candidate for studying mechanisms of detoxification, including the role of glutathione S-transferase enzymes in the biotransformation and elimination of harmful substances. Research has focused on exploring its antioxidant, anti-inflammatory, and neuroprotective characteristics. In laboratory applications, this compound has been employed to investigate its impact on various biochemical and physiological processes.
N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (mixture of diastereomers) (CAS 144889-50-9) References
- Quantitative and qualitative differences in the metabolism of 14C-1,3-butadiene in rats and mice: relevance to cancer susceptibility. | Richardson, KA., et al. 1999. Toxicol Sci. 49: 186-201. PMID: 10416264
- Dose responses for the formation of hemoglobin adducts and urinary metabolites in rats and mice exposed by inhalation to low concentrations of 1,3-[2,3-(14)C]-butadiene. | Booth, ED., et al. 2004. Chem Biol Interact. 147: 213-32. PMID: 15013822
- Alcohol dehydrogenase- and rat liver cytosol-dependent bioactivation of 1-chloro-2-hydroxy-3-butene to 1-chloro-3-buten-2-one, a bifunctional alkylating agent. | Elfarra, AA. and Zhang, XY. 2012. Chem Res Toxicol. 25: 2600-7. PMID: 23110628
- Bis-butanediol-mercapturic acid (bis-BDMA) as a urinary biomarker of metabolic activation of butadiene to its ultimate carcinogenic species. | Kotapati, S., et al. 2014. Carcinogenesis. 35: 1371-8. PMID: 24531806
- High throughput HPLC-ESI(-)-MS/MS methodology for mercapturic acid metabolites of 1,3-butadiene: Biomarkers of exposure and bioactivation. | Kotapati, S., et al. 2015. Chem Biol Interact. 241: 23-31. PMID: 25727266
- Quantitative NanoLC/NSI+-HRMS Method for 1,3-Butadiene Induced bis-N7-guanine DNA-DNA Cross-Links in Urine. | Erber, L., et al. 2021. Toxics. 9: PMID: 34678943
- Identification of novel metabolites of butadiene monoepoxide in rats and mice. | Richardson, KA., et al. 1998. Chem Res Toxicol. 11: 1543-55. PMID: 9860500
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (mixture of diastereomers), 1 mg | sc-207969 | 1 mg | $354.00 |