Molecular structure of N-Acetyl-L-tryptophan, CAS Number: 1218-34-4
N-Acetyl-L-tryptophan (CAS 1218-34-4)
Alternate Names:
N-Acetyl-Trp-OH
Application:
N-Acetyl-L-tryptophan is an inhibitor of NK-1R
CAS Number:
1218-34-4
Purity:
≥99%
Molecular Weight:
246.26
Molecular Formula:
C13H14N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
N-Acetyl-L-tryptophan is an inhibitor of NK-1R. N-Acetyl-L-tryptophan is a compound derived from tryptophan, an amino acid present in various foods and known as a precursor to serotonin. In scientific research, N-Acetyl-L-tryptophan has been employed to investigate serotonin′s involvement in diverse biochemical and physiological functions. As a serotonin agonist, N-Acetyl-L-tryptophan binds to serotonin receptors in the brain, thereby stimulating them. This activation of serotonin receptors triggers the release of serotonin.
N-Acetyl-L-tryptophan (CAS 1218-34-4) References
- Nitration and nitrosation of N-acetyl-L-tryptophan and tryptophan residues in proteins by various reactive nitrogen species. | Suzuki, T., et al. 2004. Free Radic Biol Med. 37: 671-81. PMID: 15288124
- 15N-CIDNP investigations during tryptophan, N-acetyl-L-tryptophan, and melatonin nitration with reactive nitrogen species. | Lehnig, M. and Kirsch, M. 2007. Free Radic Res. 41: 523-35. PMID: 17454135
- The NK1 receptor antagonist N-acetyl-L-tryptophan reduces dyskinesia in a hemi-parkinsonian rodent model. | Thornton, E., et al. 2014. Parkinsonism Relat Disord. 20: 508-13. PMID: 24637127
- N-acetyl-L-tryptophan delays disease onset and extends survival in an amyotrophic lateral sclerosis transgenic mouse model. | Li, W., et al. 2015. Neurobiol Dis. 80: 93-103. PMID: 25986728
- N-acetyl-l-tryptophan, but not N-acetyl-d-tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis. | Sirianni, AC., et al. 2015. J Neurochem. 134: 956-68. PMID: 26031348
- N-acetyl-L-methionine is a superior protectant of human serum albumin against post-translational oxidation as compared to N-acetyl-L-tryptophan. | Kouno, Y., et al. 2016. Biochem Biophys Rep. 6: 266-274. PMID: 28955884
- N-acetyl-L-tryptophan, a substance-P receptor antagonist attenuates aluminum-induced spatial memory deficit in rats. | Fernandes, J., et al. 2018. Toxicol Mech Methods. 28: 328-334. PMID: 29185389
- Protective role of N-acetyl-l-tryptophan against hepatic ischemia-reperfusion injury via the RIP2/caspase-1/IL-1β signaling pathway. | Wang, J., et al. 2019. Pharm Biol. 57: 385-391. PMID: 31184936
- Inhibition of excessive mitophagy by N-acetyl-L-tryptophan confers hepatoprotection against Ischemia-Reperfusion injury in rats. | Li, H., et al. 2020. PeerJ. 8: e8665. PMID: 32296597
- N-acetyl-L-tryptophan attenuates hepatic ischemia-reperfusion injury via regulating TLR4/NLRP3 signaling pathway in rats. | Pan, Y., et al. 2021. PeerJ. 9: e11909. PMID: 34434653
- Correcting a widespread error: Neuroprotectant N-acetyl-L-tryptophan does not bind to the neurokinin-1 receptor. | Matalińska, J. and Lipiński, PFJ. 2022. Mol Cell Neurosci. 120: 103728. PMID: 35421568
- N-Acetyl-l-tryptophan inhibits CCl4-induced hepatic fibrogenesis via regulating TGF-β1/SMAD and Hippo/YAP1 signal. | Ma, T., et al. 2022. Bioorg Chem. 126: 105899. PMID: 35667255
- In-vitro alleviation of ochratoxin a mediated cytotoxicity using N-acetyl-L-tryptophan glucoside pretreatment. | Agarwal, P., et al. 2022. Life Sci. 308: 120968. PMID: 36116528
- Amelioration of Radiation-Induced Cell Death in Neuro2a Cells by Neutralizing Oxidative Stress and Reducing Mitochondrial Dysfunction Using N-Acetyl-L-Tryptophan. | Kumar, R., et al. 2022. Oxid Med Cell Longev. 2022: 9124365. PMID: 36471866
- N-acetyl-L-tryptophan (NAT) provides protection to intestinal epithelial cells (IEC-6) against radiation-induced apoptosis via modulation of oxidative stress and mitochondrial membrane integrity. | Kumari, P., et al. 2023. Mol Biol Rep.. PMID: 37322322
Inhibitor of:
NK-1R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Acetyl-L-tryptophan, 5 g | sc-279677 | 5 g | $26.00 | |||
N-Acetyl-L-tryptophan, 25 g | sc-279677A | 25 g | $51.00 | |||
N-Acetyl-L-tryptophan, 100 g | sc-279677B | 100 g | $143.00 | |||
N-Acetyl-L-tryptophan, 250 g | sc-279677C | 250 g | $265.00 | |||
N-Acetyl-L-tryptophan, 1 kg | sc-279677D | 1 kg | $1012.00 |