Molecular structure of N-Acetyl-L-leucine, CAS Number: 1188-21-2
N-Acetyl-L-leucine (CAS 1188-21-2)
Alternate Names:
N-Acetylleucine; (2S)-2-acetamido-4-methylpentanoic acid
Application:
N-Acetyl-L-leucine is a derivative of L-leucine carrying an N-acylated aliphatic chain
CAS Number:
1188-21-2
Purity:
≥99%
Molecular Weight:
173.21
Molecular Formula:
C8H15NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Acetyl-L-leucine is an acetylated derivative of the amino acid leucine and is used in biochemical research. In studies of protein acetylation, this compound serves as a standard for analyzing the acetylation patterns that modulate protein function and stability. It is utilized in the synthesis of more complex peptides and in the production of isotopically labeled proteins for NMR spectroscopy, which aids in elucidating protein structures and dynamics. N-Acetyl-L-leucine is also used in metabolic studies to investigate the role of acetylation in cellular processes and energy metabolism. Additionally, its role in the synthesis of small molecules and as a building block in the chemical production of various compounds is of significant interest in organic chemistry.
N-Acetyl-L-leucine (CAS 1188-21-2) References
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- N-acetyl-L-leucine accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus. | Günther, L., et al. 2015. PLoS One. 10: e0120891. PMID: 25803613
- Comparative analysis of pharmacological treatments with N-acetyl-DL-leucine (Tanganil) and its two isomers (N-acetyl-L-leucine and N-acetyl-D-leucine) on vestibular compensation: Behavioral investigation in the cat. | Tighilet, B., et al. 2015. Eur J Pharmacol. 769: 342-9. PMID: 26607469
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- Optimization of an Ultrasound-Assisted Extraction for Simultaneous Determination of Antioxidants in Sesame with Response Surface Methodology. | Wang, D., et al. 2019. Antioxidants (Basel). 8: PMID: 31430991
- Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance. | Churchill, GC., et al. 2020. PLoS One. 15: e0229585. PMID: 32108176
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- N-Acetyl-L-leucine improves functional recovery and attenuates cortical cell death and neuroinflammation after traumatic brain injury in mice. | Hegdekar, N., et al. 2021. Sci Rep. 11: 9249. PMID: 33927281
- Acetylation turns leucine into a drug by membrane transporter switching. | Churchill, GC., et al. 2021. Sci Rep. 11: 15812. PMID: 34349180
- Pharmacotherapy of cerebellar and vestibular disorders. | Lemos, J. and Manto, M. 2022. Curr Opin Neurol. 35: 118-125. PMID: 34845147
- N-acetyl-L-leucine: a promising treatment option for traumatic brain injury. | Sarkar, C. and Lipinski, MM. 2022. Neural Regen Res. 17: 1957-1958. PMID: 35142673
- Significant metabolic alterations in non-small cell lung cancer patients by epidermal growth factor receptor-targeted therapy and PD-1/PD-L1 immunotherapy. | Yan, C., et al. 2022. Front Pharmacol. 13: 949745. PMID: 36034789
- Mass Spectrometry-Based Proteomic and Metabolomic Profiling of Serum Samples for Discovery and Validation of Tuberculosis Diagnostic Biomarker Signature. | Fernandes, AF., et al. 2022. Int J Mol Sci. 23: PMID: 36430211
- The Effects of N-Acetyl-L-Leucine on the Improvement of Symptoms in a Patient with Multiple Sulfatase Deficiency. | Saberi-Karimian, M., et al. 2022. Cerebellum. 1-7. PMID: 36482027
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Acetyl-L-leucine, 25 g | sc-257827 | 25 g | $80.00 |