Date published: 2026-5-1

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N-Acetyl-D-tryptophan (CAS 2280-01-5)

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CAS Number:
2280-01-5
Molecular Weight:
246.26
Molecular Formula:
C13H14N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-Acetyl-D-tryptophan is a compound that functions as a precursor in the synthesis of proteins and neurotransmitters. At the molecular level, N-Acetyl-D-tryptophan is involved in the biosynthesis of serotonin, where it is converted into 5-hydroxytryptophan by the enzyme tryptophan hydroxylase. N-Acetyl-D-tryptophan′s mechanism of action involves its incorporation into proteins and its conversion into serotonin, contributing to the regulation of neurotransmission and protein synthesis. Its function in these processes may be an important compound for understanding the molecular mechanisms underlying neurotransmitter regulation and protein synthesis in experimental applications.


N-Acetyl-D-tryptophan (CAS 2280-01-5) References

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  2. Studies on acylase activity and micro-organisms. XX. Isolation of soil bacteria capable of resolving trytophan by their acylase on N-acetyl-DL-tryptophan.  |  KAMEDA, Y. and ISHII, Y. 1962. Chem Pharm Bull (Tokyo). 10: 1152-3. PMID: 13962055
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  7. Annotating enzymes of uncertain function: the deacylation of D-amino acids by members of the amidohydrolase superfamily.  |  Cummings, JA., et al. 2009. Biochemistry. 48: 6469-81. PMID: 19518059
  8. N-acetyl-l-tryptophan, but not N-acetyl-d-tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis.  |  Sirianni, AC., et al. 2015. J Neurochem. 134: 956-68. PMID: 26031348
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  12. Significant metabolic alterations in non-small cell lung cancer patients by epidermal growth factor receptor-targeted therapy and PD-1/PD-L1 immunotherapy.  |  Yan, C., et al. 2022. Front Pharmacol. 13: 949745. PMID: 36034789
  13. Calorimetric investigations of the binding of inhibitors to alpha-chymotrypsin. I. The enthalpy of dilution of alpha-chymotrypsin and of proflavin, and the enthalpy of binding of indole, N-acetyl-D-tryptophan, and proflavin to alpha-chymotrypsin.  |  Shiao, DD. and Sturtevant, JM. 1969. Biochemistry. 8: 4910-7. PMID: 5391863

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Acetyl-D-tryptophan, 1 g

sc-301270
1 g
$24.00

N-Acetyl-D-tryptophan, 5 g

sc-301270A
5 g
$52.00