Date published: 2026-4-5

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N-Acetyl-Asp-Glu-OH (CAS 3106-85-2)

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Alternate Names:
α-NAAG; Spaglumic acid
Application:
N-Acetyl-Asp-Glu-OH is an endogenous neurotransmitter with high affinity for mGluR-3
CAS Number:
3106-85-2
Purity:
≥98%
Molecular Weight:
304.26
Molecular Formula:
C11H16N2O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-Acetyl-Asp-Glu-OH, an acetylated dipeptide, is utilized in biochemical research to investigate peptide interactions and stability. It serves as a building block in the synthesis of more complex peptides and proteins, providing insight into peptide bond formation and protease resistance. The compound is also used in studies of protein folding and misfolding, as it can model the behavior of larger peptides under various conditions. N-Acetyl-Asp-Glu-OH is instrumental in enzymology research, where it serves as a substrate or inhibitor to study the specificity and mechanism of action of acetyltransferases and deacetylases. Additionally, in materials science, the compound is explored for its potential in the creation of biocompatible polymers that mimic the properties of natural peptides, which are of interest for their applications in creating scaffolds for tissue engineering.


N-Acetyl-Asp-Glu-OH (CAS 3106-85-2) References

  1. The neurobiology of N-acetylaspartylglutamate.  |  Blakely, RD. and Coyle, JT. 1988. Int Rev Neurobiol. 30: 39-100. PMID: 3061970
  2. Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors.  |  Koller, KJ. and Coyle, JT. 1984. Eur J Pharmacol. 98: 193-9. PMID: 6143677
  3. N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain 'glutamate' receptor.  |  Zaczek, R., et al. 1983. Proc Natl Acad Sci U S A. 80: 1116-9. PMID: 6302671
  4. Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase.  |  Jackson, PF., et al. 1996. J Med Chem. 39: 619-22. PMID: 8558536
  5. The nagging question of the function of N-acetylaspartylglutamate.  |  Coyle, JT. 1997. Neurobiol Dis. 4: 231-8. PMID: 9361299
  6. N-acetylaspartylglutamate stimulates metabotropic glutamate receptor 3 to regulate expression of the GABA(A) alpha6 subunit in cerebellar granule cells.  |  Ghose, S., et al. 1997. J Neurochem. 69: 2326-35. PMID: 9375663
  7. N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases.  |  Passani, LA., et al. 1997. Mol Chem Neuropathol. 31: 97-118. PMID: 9376025
  8. N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo.  |  Orlando, LR., et al. 1997. Neurosci Lett. 236: 91-4. PMID: 9404819
  9. Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease.  |  Passani, LA., et al. 1997. Brain Res. 772: 9-22. PMID: 9406950

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Acetyl-Asp-Glu-OH, 10 mg

sc-202717
10 mg
$78.00

N-Acetyl-Asp-Glu-OH, 50 mg

sc-202717A
50 mg
$208.00