Molecular structure of N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO), CAS Number: 150403-88-6
N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO) (CAS 150403-88-6)
See product citations (4)
Alternate Names:
L-NIO hydrochloride;L-Ornithine ψ-acetamidine hydrochloride
Application:
N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO) is an inhibitor of NOS3
CAS Number:
150403-88-6
Purity:
≥95%
Molecular Weight:
209.67
Molecular Formula:
C7H15N3O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO), is an inhibitor of NOS3 (nitric oxide synthase) in the vascular endothelium that can halt endothelium-dependent relaxation induced by acteylcholine and cause endothelium-dependent contraction in aortic rings. Mechanistic studies have noted that L-NIO inhibits Ca2+-dependent NOS3 (eNOS). The same experiment on rat aorta has shown L-NIO to display a capacity to induce a dose-dependent increase in mean systemic arterial blood pressure. In addition, research has shown L-NIO to be the most potent inhibitor of the neutrophil and J774 enzymes compared to its analogues L-NMMA, L-NAME, and L-NNA.
N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO) (CAS 150403-88-6) References
- Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes. | Xu, Z., et al. 2005. Cardiovasc Res. 65: 803-12. PMID: 15721860
- Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. | Rees, DD., et al. 1990. Br J Pharmacol. 101: 746-52. PMID: 1706208
- Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells. | McCall, TB., et al. 1991. Br J Pharmacol. 102: 234-8. PMID: 1710525
- Norepinephrine-induced nociception and vasoconstrictor hypersensitivity in rats with chronic post-ischemia pain. | Xanthos, DN., et al. 2008. Pain. 137: 640-651. PMID: 18079061
- Intracerebroventricular injection of neuronal and inducible nitric oxide synthase inhibitors does not influence febrile response in rats during turpentine abscess. | Soszynski, D. and Chelminiak, M. 2007. J Physiol Pharmacol. 58: 657-67. PMID: 18195479
- Alterations in the activity and expression of endothelial NO synthase in aged human endothelial cells. | Yoon, HJ., et al. 2010. Mech Ageing Dev. 131: 119-23. PMID: 20064546
- Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands. | Palacios, M., et al. 1989. Biochem Biophys Res Commun. 165: 802-9. PMID: 2480784
- Pancreatic-β-cell survival and proliferation are promoted by protein kinase G type Iα and downstream regulation of AKT/FOXO1. | Wong, JC., et al. 2017. Diab Vasc Dis Res. 14: 434-449. PMID: 28631500
- Suppression of cortical TRPM7 protein attenuates oxidative damage after traumatic brain injury via Akt/endothelial nitric oxide synthase pathway. | Xu, HL., et al. 2018. Neurochem Int. 112: 197-205. PMID: 28736242
- Electroacupuncture pretreatment attenuates brain injury in a mouse model of cardiac arrest and cardiopulmonary resuscitation via the AKT/eNOS pathway. | Yong, Y., et al. 2019. Life Sci. 235: 116821. PMID: 31476306
- L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. | Moore, WM., et al. 1994. J Med Chem. 37: 3886-8. PMID: 7525961
- Possible role of nitric oxide in the development of L-2-chloropropionic acid-induced cerebellar granule cell necrosis. | Widdowson, PS., et al. 1996. Br J Pharmacol. 117: 1761-7. PMID: 8732288
- Role of endothelial nitric oxide synthase in hypoxia-induced pial artery dilation. | Wilderman, MJ. and Armstead, WM. 1998. J Cereb Blood Flow Metab. 18: 531-8. PMID: 9591845
Inhibitor of:
Enzyme, and NOS3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO), 1 mg | sc-200343 | 1 mg | $190.00 | |||
N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO), 100 mg | sc-200343A | 100 mg | $1400.00 |