Molecular structure of N-(4-Acetamidophenyl)indomethacin Amide, CAS Number: 261766-23-8
N-(4-Acetamidophenyl)indomethacin Amide (CAS 261766-23-8)
Application:
N-(4-Acetamidophenyl)indomethacin Amide is a selective reversible Cox-2 inhibitor
CAS Number:
261766-23-8
Molecular Weight:
489.95
Molecular Formula:
C27H24ClN3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-(4-Acetamidophenyl)indomethacin Amide is a potent and selective reversible Cox-2 inhibitor. N-(4-Acetamidophenyl)indomethacin Amide inhibits human Cox-2 with IC50 of 0.1 μM and ovine Cox-2 with IC50 of 0.625 μM. N-(4-Acetamidophenyl)indomethacin Amide is about 400 times less potent as an inhibitor of human Cox-1 and 80 times less potent as an inhibitor of ovine Cox-1. N-(4-Acetamidophenyl)indomethacin Amide shows anti−inflammatory, antiangiogenic, and cancer chemopreventive activity in various experimental models.
N-(4-Acetamidophenyl)indomethacin Amide (CAS 261766-23-8) References
Kalgutkar, A.S., et al.: J. Med. Chem., 43, 2860 (2000), Holt, S., et al.: Eur. J. Pharmacol., 565, 26 (2007),Inhibitor of:
Cox-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-(4-Acetamidophenyl)indomethacin Amide, 50 mg | sc-207912 | 50 mg | $330.00 |