![N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamide (CAS 457897-92-6) - chemical st](https://media.scbt.com/product/n-4--2s-3-2-3-4-dichlorophenyl-ethylamino-2-hydroxypropoxyphenyl-methanesulfonamide-457897-92-6-structure_21_33_b_213346.jpg)
![N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamide (CAS 457897-92-6) - chemical st](https://media.scbt.com/product/n-4--2s-3-2-3-4-dichlorophenyl-ethylamino-2-hydroxypropoxyphenyl-methanesulfonamide-457897-92-6-structure_21_33_t_213346.jpg "Molecular structure of N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamide, CAS Number: 457897-92-6")
N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamide (CAS 457897-92-6)
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N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. This chemical is a propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC50 = 50 nM). It does not inhibit NR1, NR2A, NR2C, and NR2D subunits and has no significant effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid (AMPA) or kainate receptors. This compound is neuroprotective, since it prevents NMDA-triggered release of lactate dehydrogenase from cultured cortical neurons. Also, when administered intraperitoneally, reduces brain infarct volume resulting from transient ischemia via carotid artery occlusion.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamide, 1 mg | sc-295632 | 1 mg | $45.00 | |||
N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamide, 5 mg | sc-295632A | 5 mg | $205.00 | |||
N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamide, 10 mg | sc-295632B | 10 mg | $360.00 | |||
N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamide, 25 mg | sc-295632C | 25 mg | $793.00 |