Date published: 2025-11-30

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N-(3-Butynyl)phthalimide (CAS 14396-90-8)

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Application:
N-(3-Butynyl)phthalimide is a terminal alkyne substituted isoindole compound for proteomics research
CAS Number:
14396-90-8
Molecular Weight:
199.21
Molecular Formula:
C12H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-(3-Butynyl)phthalimide is a compound employed in a variety of synthetic chemistry research applications. It acts as a versatile intermediate for the introduction of the phthalimide moiety, which is a pivotal functional group in the synthesis of diverse organic molecules. The compound′s alkyne functional group is particularly reactive under Sonogashira coupling conditions, a feature that researchers exploit to create complex carbon-rich structures. In addition, its utility in the field of polymer science is notable, with studies investigating its incorporation into novel polymer backbones to alter physical properties such as rigidity and thermal resistance. Moreover, N-(3-Butynyl)phthalimide is used as a probe in mechanistic studies to better understand the dynamics of conjugation and electron distribution, essential concepts for the advancement of functional materials and sensing technologies.


N-(3-Butynyl)phthalimide (CAS 14396-90-8) References

  1. Extension of furopyrimidine nucleosides with 5-alkynyl substituent: Synthesis, high fluorescence, and antiviral effect in the absence of free ribose hydroxyl groups.  |  Kaczmarek, R., et al. 2021. Eur J Med Chem. 209: 112884. PMID: 33039724
  2. Design and Synthesis of Water-Soluble and Potent MMP-13 Inhibitors with Activity in Human Osteosarcoma Cells.  |  Zapico, JM., et al. 2021. Int J Mol Sci. 22: PMID: 34576138
  3. Strategies to Generate Nitrogen-centered Radicals That May Rely on Photoredox Catalysis: Development in Reaction Methodology and Applications in Organic Synthesis.  |  Kwon, K., et al. 2022. Chem Rev. 122: 2353-2428. PMID: 34623809
  4. Incorporation of Conjugated Diynes in Perovskites and their Post-Synthetic Modification.  |  Román-Román, PI., et al. 2023. ChemSusChem. 16: e202201505. PMID: 36445827
  5. 'Clickable' Organic Electrochemical Transistors.  |  Fenoy, GE., et al. 2022. JACS Au. 2: 2778-2790. PMID: 36590273
  6. Interface Engineering of 'Clickable' Organic Electrochemical Transistors toward Biosensing Devices.  |  Fenoy, GE., et al. 2023. ACS Appl Mater Interfaces. 15: 10885-10896. PMID: 36791086

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-(3-Butynyl)phthalimide, 5 g

sc-255318
5 g
$71.00