Molecular structure of N-(3-Aminopropyl)cyclohexylamine, CAS Number: 3312-60-5
N-(3-Aminopropyl)cyclohexylamine (CAS 3312-60-5)
See product citations (3)
Alternate Names:
N-Cyclohexyl-1,3-propanediamine
Application:
N-(3-Aminopropyl)cyclohexylamine is a competitive inhibitor of spermine and spermidine synthases
CAS Number:
3312-60-5
Purity:
>97% (contains traces of water)
Molecular Weight:
156.30
Molecular Formula:
C9H20N2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-(3-Aminopropyl)cyclohexylamine is an inhibitor of SPSY (spermine synthase). N-(3-Aminopropyl)cyclohexylamine is described to specifically deplete rat hepatoma cells of spermidine and spermine levels in culture. N-(3-Aminopropyl)cyclohexylamine is described to antagonize the facilitating effect of spermidine on NMDLA-induced seizures, suggesting the usefulness of N-(3-Aminopropyl)cyclohexylamine as a tool for studying neuromodulatory polyamines. N-(3-Aminopropyl)cyclohexylamine is an inhibitor of SPDSY.
N-(3-Aminopropyl)cyclohexylamine (CAS 3312-60-5) References
- Electrospray ionization and time-of-flight mass spectrometric method for simultaneous determination of spermidine and spermine. | Samejima, K., et al. 2007. Biol Pharm Bull. 30: 1943-6. PMID: 17917267
- Spermidine regulates insulin synthesis and cytoplasmic Ca(2+) in mouse beta-TC6 insulinoma cells. | Ohtani, M., et al. 2009. Cell Struct Funct. 34: 105-13. PMID: 19875898
- Putrescine or spermidine binding site of aminopropyltransferases and competitive inhibitors. | Shirahata, A., et al. 1991. Biochem Pharmacol. 41: 205-12. PMID: 1989632
- Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells. | Ishii, I., et al. 2012. Amino Acids. 42: 619-26. PMID: 21809076
- Stimulating effect of spermine on bulblet formation in bulb-scale segments of Lilium longiflorum. | Tanimoto, S. and Matsubara, Y. 1995. Plant Cell Rep. 15: 297-300. PMID: 24185796
- A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail. | Burger, PB., et al. 2015. Malar J. 14: 54. PMID: 25651815
- Host-Guest Interaction of Cucurbit[8]uril with N-(3-Aminopropyl)cyclohexylamine: Cyclohexyl Encapsulation Triggered Ternary Complex. | Xia, Y., et al. 2018. Molecules. 23: PMID: 29342978
- Spermine synthesis inhibitor blocks 25-hydroxycholesterol-induced- apoptosis via SREBP2 upregulation in DLD-1 cell spheroids. | Kakimoto, M., et al. 2020. Biochem Biophys Rep. 22: 100754. PMID: 32258442
- Substituted 3,4,5-trimethoxybenzamides: correlation between inhibition of pyruvic acid oxidation and anticonvulsant activity. | Chaturvedi, AK., et al. 1972. J Pharm Sci. 61: 1157-60. PMID: 5044820
- Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases. | Beppu, T., et al. 1995. J Biochem. 117: 339-45. PMID: 7608122
- N-(3-aminopropyl)-cyclohexylamine blocks facilitation by spermidine of N-methyl-DL-aspartate-induced seizure in mice in vivo. | Chu, PJ., et al. 1994. Eur J Pharmacol. 256: 155-60. PMID: 8050466
- Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues. | Shirahata, A., et al. 1993. Biochem Pharmacol. 45: 1897-903. PMID: 8494549
- Antagonistic effect of N-(3-Aminopropyl)cyclohexylamine on neurotrophic action of spermine in primary cultured rat hippocampal and cerebellar neurons. | Chu, PJ., et al. 1995. Jpn J Pharmacol. 69: 311-5. PMID: 8786633
Inhibitor of:
ALKB, SPDSY, and SPSY.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-(3-Aminopropyl)cyclohexylamine, 1 g | sc-202715 | 1 g | $37.00 | |||
N-(3-Aminopropyl)cyclohexylamine, 5 g | sc-202715D | 5 g | $43.00 | |||
N-(3-Aminopropyl)cyclohexylamine, 10 g | sc-202715A | 10 g | $52.00 | |||
N-(3-Aminopropyl)cyclohexylamine, 25 g | sc-202715B | 25 g | $67.00 | |||
N-(3-Aminopropyl)cyclohexylamine, 100 g | sc-202715C | 100 g | $213.00 |