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![N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester (CAS 615264-52-3) - chemical structure image](https://media.scbt.com/product/n-3-4-hydroxyphenyl-1-oxo-2-propenyl-l-phenylalanine-methyl-ester-615264-52-3-structure_29_43_t_294341.jpg "Molecular structure of N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester, CAS Number: 615264-52-3")
Molecular structure of N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester, CAS Number: 615264-52-3
N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester (CAS 615264-52-3)
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Alternate Names:
4-Hydroxycinnamic acid (L-phenylalanine methyl ester) amide
Application:
N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester is an inhibitor of ACAT-1 and -2
CAS Number:
615264-52-3
Purity:
≥98%
Molecular Weight:
325.36
Molecular Formula:
C19H19NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester, inhibits human Acyl-Coenzyme A cyltransferase-1 and -2 (ACAT-1 and ACAT-2) equally (IC50 ~ 60 muM). ACAT-1 and ACAT-2 catalyze the formation of long chain fatty acyl-coenzyme A and cholesterol esters from cholesterol, and may play a role in the development of atherosclerosis. Additionally, at a concentration of 3muM, N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester, demonstrates ~28% inhibition of copper-mediated oxidation of low density lipoproteins.
N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester (CAS 615264-52-3) References
- Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates. | Lee, RG., et al. 2000. J Lipid Res. 41: 1991-2001. PMID: 11108732
- Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis. | Rudel, LL., et al. 2001. Curr Opin Lipidol. 12: 121-7. PMID: 11264983
- Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. | Lee, S., et al. 2004. Bioorg Med Chem Lett. 14: 4677-81. PMID: 15324887
Inhibitor of:
ACAT-1, and ACAT-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester, 5 mg | sc-221976 | 5 mg | $45.00 | |||
N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester, 10 mg | sc-221976A | 10 mg | $87.00 |