Molecular structure of N-(2-Mercaptoethyl) Demecolcine, CAS Number: 1217746-74-1
N-(2-Mercaptoethyl) Demecolcine (CAS 1217746-74-1)
Application:
N-(2-Mercaptoethyl) Demecolcine is A labeled antimitotic agent
CAS Number:
1217746-74-1
Molecular Weight:
431.55
Molecular Formula:
C23H29NO5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
An antimitotic agent which disrupts microtubles by binding to tubulin and preventing its polyerization. Stimulates the intrinsic GTPase activity of tubulin.
N-(2-Mercaptoethyl) Demecolcine (CAS 1217746-74-1) References
- Tubulin structure and biochemistry. | Ludueña, RF., et al. 1992. Curr Opin Cell Biol. 4: 53-7. PMID: 1558754
- Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. | Ceccatelli, S., et al. 1997. Neuroreport. 8: 3779-83. PMID: 9427370
- Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. | Wang, TH., et al. 1998. J Biol Chem. 273: 4928-36. PMID: 9478937
- Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. | Andreu, JM., et al. 1998. Biochemistry. 37: 8356-68. PMID: 9622487
Inhibitor of:
Tubulin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-(2-Mercaptoethyl) Demecolcine, 10 mg | sc-218920 | 10 mg | $380.00 |