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N-(1-Naphthyl)ethylenediamine dihydrochloride (CAS 1465-25-4)

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Alternate Names:
2-(1-Naphthylamino)ethylamine dihydrochloride
Application:
N-(1-Naphthyl)ethylenediamine dihydrochloride is a coupling agent for spectrophotometric analysis
CAS Number:
1465-25-4
Purity:
≥98%
Molecular Weight:
259.17
Molecular Formula:
C12H14N22HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-(1-Naphthyl)ethylenediamine dihydrochloride, with the chemical formula C12H14N2·2HCl, is a derivative of ethylenediamine where one of the hydrogen atoms is replaced by a naphthyl group. This compound is a solid at room temperature and is highly valued in analytical chemistry, particularly in colorimetric assays. Its primary utility stems from its ability to form highly colored complexes with certain metal ions and organic compounds, making it an excellent reagent for the detection and quantification of these substances. One of the classic applications of N-(1-Naphthyl)ethylenediamine dihydrochloride is in the development of chromogenic substrates where it reacts with specific compounds to produce a vivid color change. This property is particularly exploited in the assay of sulfonamides, where it reacts under acidic conditions with nitrite to form a bright pink azo dye, a basis for quantifying sulfonamide concentrations in various samples. In environmental research, this reagent is used to measure nitrate and nitrite levels in water, providing essential data for monitoring water quality and studying nutrient cycling in aquatic ecosystems. Additionally, its role extends into the field of materials science, where it is used in the synthesis of organic dyes and pigments, exploring the interactions and stability of naphthyl-based compounds in different chemical environments.


N-(1-Naphthyl)ethylenediamine dihydrochloride (CAS 1465-25-4) References

  1. Bioassay of N-(1-naphthyl)ethylenediamine dihydrochloride for possible carcinogenicity.  |  ,. 1979. Natl Cancer Inst Carcinog Tech Rep Ser. 168: 1-103. PMID: 12799695
  2. AN OBSERVATION CONCERNING THE BRATTON-MARSHALL DIAZO REACTION IN SULFONAMIDE-FREE URINE.  |  ANNINO, JS. 1964. Clin Chem. 10: 370-1. PMID: 14165566
  3. Quantitation of nicorandil in pharmaceutical formulations by spectrophotometry using N-(1-naphthyl) ethylenediamine dihydrochloride as coupling agent.  |  Rahman, N., et al. 2007. Yakugaku Zasshi. 127: 367-74. PMID: 17268157
  4. Continued investigation of the diazotization and coupling spectrophotometric technique for the determination of aromatic amines with 8-amino-1-hydroxynaphthalene-3,6-disulphonic acid and N-(1-naphthyl)ethylenediamine as coupling agents.  |  Norwitz, G. and Keliher, PN. 1986. Talanta. 33: 311-4. PMID: 18964089
  5. Manual and flow-injection spectrophotometric assay of thiols, based on their S-nitrosation.  |  Verma, KK., et al. 1991. Talanta. 38: 283-9. PMID: 18965141
  6. Development of a selective and sensitive spectrophotometric method for the trace determination of thallium(III) using 3-methyl-2-benzothiazolinone hydrazone hydrochloride and N-(1-naphthyl)-ethylenediamine dihydrochloride.  |  Nagaraja, P., et al. 2008. J AOAC Int. 91: 1116-23. PMID: 18980127
  7. Determination of peimine and peiminine in Bulbus Fritillariae Thunbergii by capillary electrophoresis by indirect UV detection using N-(1-naphthyl)ethylenediamine dihydrochloride as probe.  |  Liu, L., et al. 2012. Electrophoresis. 33: 2152-8. PMID: 22821492
  8. Ammonia-treated N-(1-naphthyl) ethylenediamine dihydrochloride as a novel matrix for rapid quantitative and qualitative determination of serum free fatty acids by matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry.  |  Zhang, Y., et al. 2013. Anal Chim Acta. 794: 82-9. PMID: 23972979
  9. MALDI-TOF MS imaging of metabolites with a N-(1-naphthyl) ethylenediamine dihydrochloride matrix and its application to colorectal cancer liver metastasis.  |  Wang, J., et al. 2015. Anal Chem. 87: 422-30. PMID: 25474421
  10. N-(1-naphthyl)ethylenediamine dihydrochloride as a new reagent for nanomole quantification of sugars on thin-layer plates by a mathematical calibration process.  |  Bounias, M. 1980. Anal Biochem. 106: 291-5. PMID: 7446996

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-(1-Naphthyl)ethylenediamine dihydrochloride, 5 g

sc-203148
5 g
$41.00

N-(1-Naphthyl)ethylenediamine dihydrochloride, 10 g

sc-203148A
10 g
$42.00

N-(1-Naphthyl)ethylenediamine dihydrochloride, 25 g

sc-203148B
25 g
$140.00

N-(1-Naphthyl)ethylenediamine dihydrochloride, 100 g

sc-203148C
100 g
$237.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. N-(1-Naphthyl)ethylenediamine dihydrochloride, sc-203148, is a grey solid.
Answered by: Chemical Support 4
Date published: 2017-06-29

Dear Madam/Sir, Do you have "N-(1-Naphthyl)ethylenediamine dihydrochloride" 10 g available right now? How much is the purity? How long it would take time to send it to Belgium? Kind regards, FK

Asked by: FKKUL
Thank you for your question. The purity for this biochemical is >98%. For accurate availability and shipping information regarding of our chemical products, please contact our Customer Service group. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com.
Answered by: Tech Service
Date published: 2017-06-08
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Rated 5 out of 5 by from Wang J; et alWang J; et al. (PubMed ID: 25474421) determined that N-(1-Naphthyl)ethylenediamine dihydrochloride assisted laser desorption/ionization time-of-flight mass spectrometry will allow for determining biomarkers, signaling pathways, and disease mechanisms, in situ. -SCBT Publication Review
Date published: 2015-06-27
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N-(1-Naphthyl)ethylenediamine dihydrochloride is rated 5.0 out of 5 by 1.
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