Molecular structure of N-(1,3,4-Thiadiazolyl)nicotinamide, CAS Number: 51987-99-6
N-(1,3,4-Thiadiazolyl)nicotinamide (CAS 51987-99-6)
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Alternate Names:
TGN-020; N-(1,3,4-Thiadiazol-2-yl)pyridine-3-carboxamide; N-(1,3,4-Thiadiazolyl)-m-nicotinamide
Application:
N-(1,3,4-Thiadiazolyl)nicotinamide is a thiadiazole derivative studied for its potential antitumor properties
CAS Number:
51987-99-6
Molecular Weight:
206.22
Molecular Formula:
C8H6N4OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-(1,3,4-Thiadiazolyl)nicotinamide is a thiadiazole derivative which has been studied as an antitumoragent. Furthermore, N-(1,3,4-Thiadiazolyl)nicotinamide is an inhibitor of Aquaporin 4 (AQP4), the most abundant water channel in brain. Aquaporins (AQPs) are water channels required for maintaining fluid homeostasis and enabling water movement across barrier membranes, but can enhance pathological cellular volume changes and cause edema in injury states. Pretreatment with the AQP4 inhibitor N-(1,3,4-Thiadiazolyl)nicotinamide significantly reduced the volume of brain edema associated with ischemic injury in a mouse model of focal cerebral ischemia.
N-(1,3,4-Thiadiazolyl)nicotinamide (CAS 51987-99-6) References
- Astrocytic Modulation of Supraoptic Oxytocin Neuronal Activity in Rat Dams with Pup-Deprivation at Different Stages of Lactation. | Li, D., et al. 2021. Neurochem Res. 46: 2601-2611. PMID: 32930948
- Alleviation of Cerebral Infarction of Rats With Middle Cerebral Artery Occlusion by Inhibition of Aquaporin 4 in the Supraoptic Nucleus. | Cui, D., et al. 2020. ASN Neuro. 12: 1759091420960550. PMID: 32985231
- Alleviation of brain injury by applying TGN-020 in the supraoptic nucleus via inhibiting vasopressin neurons in rats of focal ischemic stroke. | Cui, D., et al. 2021. Life Sci. 264: 118683. PMID: 33127515
Inhibitor of:
AQP5.Activator of:
Mucin 5AC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-(1,3,4-Thiadiazolyl)nicotinamide, 5 mg | sc-211946 | 5 mg | $185.00 |