![N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester (CAS 778624-05-8) - chemical structure image](https://media.scbt.com/product/n--2e-3-3-4-dihydroxyphenyl-1-oxo-2-propenyl-l-alanine-methyl-ester-778624-05-8-structure_07_35_b_73570.jpg)
![N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester (CAS 778624-05-8) - chemical structure image](https://media.scbt.com/product/n--2e-3-3-4-dihydroxyphenyl-1-oxo-2-propenyl-l-alanine-methyl-ester-778624-05-8-structure_07_35_t_73570.jpg "Molecular structure of N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester, CAS Number: 778624-05-8")
Molecular structure of N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester, CAS Number: 778624-05-8
N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester (CAS 778624-05-8)
Alternate Names:
3,4-Dihydrocinnamic Acid (L-alanine methyl ester) amide
Application:
N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester is which inhibits the formation of fatty streak lesions
CAS Number:
778624-05-8
Molecular Weight:
265.26
Molecular Formula:
C13H15NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Early stage atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. This compound inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without significantly inhibiting ACAT-1 or ACAT-2 activity or affecting plasma lipid profiles.1,2 The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% CAY10487 in the diet was 16.1% compared to 53.5% in control rabbits.1 CAY10487 also exhibits antioxidant activity, inhibiting copper-mediated oxidation of low-density lipoprotein by about 75% at a concentration of 2 µM.2
N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester (CAS 778624-05-8) References
- Anti-atherogenic effects of 3,4-Dihydroxy hydrocinnamides. | Lee, S., et al. 2003. Bioorg Med Chem Lett. 13: 2681-2. PMID: 12873493
- Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. | Lee, S., et al. 2004. Bioorg Med Chem Lett. 14: 4677-81. PMID: 15324887
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester, 5 mg | sc-205398 | 5 mg | $28.00 | |||
N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester, 10 mg | sc-205398A | 10 mg | $53.00 |