MZF-1 Antibody (1F7): sc-293218

MZF-1 Antibody (1F7) is a mouse monoclonal IgG1 kappa light chain antibody that detects MZF-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-MZF-1 antibody (1F7) is available as the non-conjugated format. Myeloid zinc finger 1 (MZF-1), also known as Zinc finger protein 42 or transcription factor ZBP-89, is a member of the Krüppel C2H2-type zinc-finger protein family, which plays a crucial role in the regulation of gene expression. MZF-1 is primarily located in the nucleus, where MZF-1 functions as a transcriptional regulator during hemopoietic development and myeloid cell differentiation. Nuclear localization of MZF-1 is essential for modulating the transcription of target genes, including the CD34 promoter, in a tissue-specific manner. MZF-1 is induced by retinoic acid and is predominantly expressed in differentiating myeloid cells, highlighting MZF-1′s importance in hematopoiesis. Additionally, MZF-1 can form high molecular mass complexes with other nuclear proteins, further emphasizing MZF-1′s role in transcriptional regulation and cellular differentiation processes. The gene encoding MZF-1 is mapped to chromosome 19q13.43, underscoring MZF-1′s genetic significance in human biology.

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MZF-1 Antibody (1F7) References:

1. Reduced folate carrier gene silencing in multiple antifolate-resistant tumor cell lines is due to a simultaneous loss of function of multiple transcription factors but not promoter methylation.  |  Rothem, L., et al. 2004. J Biol Chem. 279: 374-84. PMID: 14551190
2. Allele-specific binding to the -308 single nucleotide polymorphism site in the tumour necrosis factor-alpha promoter.  |  Baseggio, L., et al. 2004. Eur J Immunogenet. 31: 15-9. PMID: 15009176
3. TAIL1: an isthmin-like gene, containing type 1 thrombospondin-repeat and AMOP domain, mapped to ARVD1 critical region.  |  Rossi, V., et al. 2004. Gene. 335: 101-8. PMID: 15194193
4. FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1.  |  Takahashi, K., et al. 2005. Biochem J. 386: 191-200. PMID: 15453830
5. LDOC1, a novel MZF-1-interacting protein, induces apoptosis.  |  Inoue, M., et al. 2005. FEBS Lett. 579: 604-8. PMID: 15670815
6. A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells.  |  Hromas, R., et al. 1991. J Biol Chem. 266: 14183-7. PMID: 1860835
7. Expression of protein kinase C α and the MZF-1 and Elk-1 transcription factors in human breast cancer cells.  |  Yue, CH., et al. 2012. Chin J Physiol. 55: 31-6. PMID: 22242952
8. Myeloid zinc-finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress.  |  Chen, Y., et al. 2015. Oncogene. 34: 3839-47. PMID: 25284586
9. MZF-1/Elk-1/PKCα is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma.  |  Ye, JC., et al. 2017. J Cancer. 8: 3028-3036. PMID: 28928894
10. Regulation of expression of MLAA-34 gene through transcriptional factors E2F1 and MZF-1.  |  Lei, B., et al. 2019. Int J Clin Exp Pathol. 12: 2100-2110. PMID: 31934032
11. BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine.  |  Kanojia, D., et al. 2020. Sci Transl Med. 12: PMID: 32848091
12. The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in vitro.  |  Morris, JF., et al. 1995. Blood. 86: 3640-7. PMID: 7579328

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MZF-1 Antibody (1F7) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-MZF-1 Antibody (1F7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MZF-1 Antibody (1F7) Specifications

Alternate Product Name: MZF-1

Product Clone Name: 1F7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 419-518

Epitope Target: MZF-1

Epitope Species: human

Product Reactivity/Detection: MZF-1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for MZF-1 Antibody (1F7): N/A