Myotrophin Antibody (B-9): sc-166672

Myotrophin Antibody (B-9) is a mouse monoclonal IgG2b antibody that detects Myotrophin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Myotrophin is a 117 amino acid protein that plays a crucial role in the differentiation of cerebellar neurons, particularly granule cells, which are essential for proper cerebellar function and motor coordination. Myotrophin is ubiquitously expressed in the cytoplasm but can translocate to the nucleus during sustained activation of nuclear factor kappa B (NFκB), highlighting Myotrophin′s involvement in cellular signaling pathways that regulate gene expression in response to stress. The gene encoding Myotrophin is located on chromosome 7q33, and Myotrophin′s structure includes an acetylated N-terminus and two internal ankyrin repeats, which are important for protein-protein interactions and may influence functional properties. Myotrophin has been associated with cardiac hypertrophy, as Myotrophin can induce the expression of protooncogenes such as ANF and β-Myosin heavy chain, particularly under conditions of cyclic stretch or inflammatory stimuli like tumor necrosis factor α (TNFα) and interleukin-1β. Notably, Myotrophin is most abundantly expressed in the brain, with significantly lower levels found in skeletal muscle, underscoring Myotrophin′s specialized roles in neuronal and cardiac physiology.

The preferred Myotrophin antibody is Myotrophin Antibody (D-3): sc-166072.