Myosin Vb Antibody (18): sc-135995

Myosin Vb Antibody (18) is a mouse monoclonal IgG1 kappa light chain antibody that detects Myosin Vb protein of mouse and rat origin by western blotting (WB) and immunoprecipitation (IP). Anti-Myosin Vb antibody (18) is available as a non-conjugated format. Myosin Vb (18) monoclonal antibody recognizes MYO5B, a crucial 1,849 amino acid protein that plays a significant role in intracellular trafficking, particularly in transporting glutamate receptors from recycling endosomes to synaptic sites, essential for synaptic plasticity and long-term potentiation. MYO5B belongs to class V unconventional myosins, which are nonfilamentous, actin-binding enzymes expressed throughout various tissues. Myosin Vb (18) antibody targets a protein whose function depends on interaction with Rab 8A, a small GTPase regulating vesicle transport, highlighting MYO5B′s importance in maintaining proper synaptic function and neuronal communication. MYO5B is also necessary for insulin-induced translocation of Glut4 in muscle cells, emphasizing its role in cellular metabolism and signaling pathways.

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Myosin Vb Antibody (18) References:

1. Mechanoenzymatic characterization of human myosin Vb.  |  Watanabe, S., et al. 2006. Biochemistry. 45: 2729-38. PMID: 16489766
2. Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.  |  Roland, JT., et al. 2007. Mol Biol Cell. 18: 2828-37. PMID: 17507647
3. Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation.  |  Ishikura, S. and Klip, A. 2008. Am J Physiol Cell Physiol. 295: C1016-25. PMID: 18701652
4. MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity.  |  Müller, T., et al. 2008. Nat Genet. 40: 1163-5. PMID: 18724368
5. Rapid recycling of beta-adrenergic receptors is dependent on the actin cytoskeleton and myosin Vb.  |  Millman, EE., et al. 2008. Traffic. 9: 1958-71. PMID: 18785920
6. Myosin learns to recruit AMPA receptors.  |  Perlson, E. and Holzbaur, EL. 2008. Cell. 135: 414-5. PMID: 18984153
7. Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity.  |  Wang, Z., et al. 2008. Cell. 135: 535-48. PMID: 18984164
8. Alternative splicing in class V myosins determines association with Rab10.  |  Roland, JT., et al. 2009. J Biol Chem. 284: 1213-23. PMID: 19008234
9. Myosin Vb mediates Cu+ export in polarized hepatocytes.  |  Gupta, A., et al. 2016. J Cell Sci. 129: 1179-89. PMID: 26823605
10. Coordinated activities of Myosin Vb isoforms and mTOR signaling regulate epithelial cell morphology during development.  |  Gupta, K., et al. 2022. Development. 149: PMID: 35299238
11. Myosin Vb as a tumor suppressor gene in intestinal cancer.  |  Cartón-García, F., et al. 2022. Oncogene. 41: 5279-5288. PMID: 36316444
12. Coronavirus M Protein Trafficking in Epithelial Cells Utilizes a Myosin Vb Splice Variant and Rab10.  |  Lapierre, LA., et al. 2024. Cells. 13: PMID: 38247817

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Myosin Vb Antibody (18) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Myosin Vb Antibody (18) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Myosin Vb Antibody (18) Specifications

Alternate Product Name: Myosin Vb

Product Clone Name: 18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 940-1051

Epitope Target: Myosin Vb

Epitope Species: rat

Product Reactivity/Detection: Myosin Vb

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Myosin Vb Antibody (18): N/A