Myosin IIIa Antibody (RR-8): sc-100953
- Myosin IIIa Antibody (RR-8) is a mouse monoclonal IgG2b κ Myosin IIIa antibody provided at 50 µg/0.5 ml
- raised against recombinant Myosin IIIa of human origin
- recommended for detection of Myosin IIIa of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Myosin IIIa Antibody (RR-8). This work is in progress.
Myosin IIIa Antibody (RR-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects Myosin IIIa protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Myosin IIIa antibody (RR-8) is available as a non-conjugated format. Myosin IIIa, also known as MYO3A or DFNB30, is a 1,616 amino acid class III myosin that plays a crucial role in cellular motility and signaling. Myosin IIIa (RR-8) monoclonal antibody recognizes a protein characterized by one protein kinase domain, one myosin head-like domain, and three IQ domains, which are essential for interaction with actin filaments. Myosin IIIa is predominantly expressed in the pancreas, cochlea, and retinal pigment cells, highlighting its importance in both auditory and visual functions. MYO3A′s kinase activity allows phosphorylation of various target proteins, thereby influencing multiple signaling pathways. Notably, mutations in the MYO3A gene are linked to non-syndromic sensorineural deafness autosomal recessive type 30 (DFNB30), underscoring Myosin IIIa′s significance in sensory perception. Anti-Myosin IIIa antibody (RR-8) enables valuable insights into the molecular mechanisms underlying these critical biological processes.
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Myosin IIIa Antibody (RR-8) References:
- Cloning and chromosomal localization of a human class III myosin. | Dosé, AC. and Burnside, B. 2000. Genomics. 67: 333-42. PMID: 10936054
- From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30. | Walsh, T., et al. 2002. Proc Natl Acad Sci U S A. 99: 7518-23. PMID: 12032315
- Determination of human myosin III as a motor protein having a protein kinase activity. | Komaba, S., et al. 2003. J Biol Chem. 278: 21352-60. PMID: 12672820
- Localization of a class III myosin to filopodia tips in transfected HeLa cells requires an actin-binding site in its tail domain. | Les Erickson, F., et al. 2003. Mol Biol Cell. 14: 4173-80. PMID: 14517327
- Human myosin III is a motor having an extremely high affinity for actin. | Kambara, T., et al. 2006. J Biol Chem. 281: 37291-301. PMID: 17012748
- A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression. | Schneider, ME., et al. 2006. J Neurosci. 26: 10243-52. PMID: 17021180
- Kinetic mechanism of human myosin IIIA. | Dosé, AC., et al. 2007. J Biol Chem. 282: 216-31. PMID: 17074769
- The kinase domain alters the kinetic properties of the myosin IIIA motor. | Dosé, AC., et al. 2008. Biochemistry. 47: 2485-96. PMID: 18229949
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Myosin IIIa Antibody (RR-8) | sc-100953 | 50 µg/0.5 ml | $339.00 |