myomegalin Antibody (S-17): sc-100921

myomegalin Antibody (S-17) is a mouse monoclonal IgG2a kappa light chain antibody that detects myomegalin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-myomegalin antibody (S-17) is available as the non-conjugated form. Myomegalin, also known as PDE4DIP (Phosphodiesterase 4D-interacting protein), CMYA2 (Cardiomyopathy-associated protein 2), or MMGL, is a 2,346 amino acid protein characterized by the presence of one NBPF domain. Myomegalin (S-17) antibody localizes predominantly in the nucleus, cytoplasm, centrosome, and Golgi apparatus, which is crucial for its role in cellular signaling. Myomegalin shows high expression in both fetal and adult heart tissues, with lower expression levels found in the brain and placenta. Myomegalin functions as an anchoring protein that sequesters components of the cAMP-dependent signaling pathway to the Golgi and centrosomes, thereby regulating the dynamics of cAMP signaling, which is vital for various cellular processes including cell proliferation and differentiation. Notably, translocations in the gene encoding myomegalin have been linked to myeloproliferative disorders, a group of diseases characterized by the overproduction of blood cells. Additionally, myomegalin exists in twelve isoforms due to alternative splicing, which may contribute to its diverse functional roles in different tissues.

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myomegalin Antibody (S-17) References:

1. Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase.  |  Verde, I., et al. 2001. J Biol Chem. 276: 11189-98. PMID: 11134006
2. Isolation of novel heart-specific genes using the BodyMap database.  |  Soejima, H., et al. 2001. Genomics. 74: 115-20. PMID: 11374908
3. Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib.  |  Wilkinson, K., et al. 2003. Blood. 102: 4187-90. PMID: 12907457
4. Cytoskeletal genes regulating brain size.  |  Bond, J. and Woods, CG. 2006. Curr Opin Cell Biol. 18: 95-101. PMID: 16337370
5. Myocardial phosphodiesterases and regulation of cardiac contractility in health and cardiac disease.  |  Osadchii, OE. 2007. Cardiovasc Drugs Ther. 21: 171-94. PMID: 17373584

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-myomegalin Antibody (S-17) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-myomegalin Antibody (S-17) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

myomegalin Antibody (S-17) Specifications

Alternate Product Name: myomegalin

Product Clone Name: S-17

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-178

Epitope Target: myomegalin

Epitope Species: human

Product Reactivity/Detection: myomegalin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for myomegalin Antibody (S-17): N/A