MYL2 Antibody (AT3B2): sc-517414
- MYL2 Antibody (AT3B2) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 1-166 of MYL2 of human origin
- recommended for detection of MYL2 of mouse and rat origin by WB, IF, FCM and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MYL2 Antibody (AT3B2). This work is in progress.
MYL2 Antibody (AT3B2) is a mouse monoclonal IgG2b antibody that detects myosin regulatory light chain 2 (MYL2) in mouse and rat samples through applications such as western blotting (WB), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-MYL2 antibody (AT3B2) plays a crucial role in cardiac muscle function, as MYL2 is integral to the contractile apparatus of cardiac myocytes, facilitating muscle contraction through interaction with myosin heavy chains. MYL2 is predominantly located in adult cardiac ventricle muscle, where MYL2 forms part of a hexameric complex essential for proper heart functioning. Precise localization of MYL2 is vital for maintaining structural integrity and contractile efficiency of cardiac tissue, and MYL2 expression is a key marker for cardiac chamber specification. Notably, mutations in MYL2 have been linked to various forms of hypertrophic cardiomyopathy, underscoring MYL2′s importance in cardiac health and disease. With high homology between human and mouse sequences, MYL2 monoclonal antibody (AT3B2) is an invaluable tool for researchers studying cardiac function and related pathologies.
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MYL2 Antibody (AT3B2) References:
- Localization of the gene coding for ventricular myosin regulatory light chain (MYL2) to human chromosome 12q23-q24.3. | Macera, MJ., et al. 1992. Genomics. 13: 829-31. PMID: 1386340
- Slow cardiac myosin regulatory light chain 2 (MYL2) was down-expressed in chronic heart failure patients. | Li, Y., et al. 2011. Clin Cardiol. 34: 30-4. PMID: 21259275
- Recessive MYL2 mutations cause infantile type I muscle fibre disease and cardiomyopathy. | Weterman, MA., et al. 2013. Brain. 136: 282-93. PMID: 23365102
- Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice. | Yuan, CC., et al. 2018. Proc Natl Acad Sci U S A. 115: E2338-E2347. PMID: 29463717
- Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with MYL2-R58Q-Mediated Apical Hypertrophic Cardiomyopathy Show Hypertrophy, Myofibrillar Disarray, and Calcium Perturbations. | Zhou, W., et al. 2019. J Cardiovasc Transl Res. 12: 394-403. PMID: 30796699
- Therapeutic potential of AAV9-S15D-RLC gene delivery in humanized MYL2 mouse model of HCM. | Yadav, S., et al. 2019. J Mol Med (Berl). 97: 1033-1047. PMID: 31101927
- MYL2-associated congenital fiber-type disproportion and cardiomyopathy with variants in additional neuromuscular disease genes; the dilemma of panel testing. | Marttila, M., et al. 2019. Cold Spring Harb Mol Case Stud. 5: PMID: 31127036
- Novel Missense Variant in MYL2 Gene Associated With Hypertrophic Cardiomyopathy Showing High Incidence of Restrictive Physiology. | De Bortoli, M., et al. 2020. Circ Genom Precis Med. 13: e002824. PMID: 32004434
- Single-cell transcriptomics reveals writers of RNA modification-mediated immune microenvironment and cardiac resident Macro-MYL2 macrophages in heart failure. | Yang, YL., et al. 2024. BMC Cardiovasc Disord. 24: 432. PMID: 39152369
- LncRNA TCL6 regulates miR-876-5p/MYL2 axis to suppress breast cancer progression. | Liu, Y., et al. 2025. Transl Oncol. 53: 102210. PMID: 39874729
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MYL2 Antibody (AT3B2) | sc-517414 | 100 µg/ml | $322.00 |