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Mycophenolic Acid-d3 β-D-Glucuronide (CAS 31528-44-6 (unlabeled))

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Alternate Names:
Mycophenolic Acid-d3 Glucosiduronate; Mycophenolic Acid-d3 Glucuronide
Application:
Mycophenolic Acid-d3 β-D-Glucuronide is a labeled inhibitor of IMPDH
CAS Number:
31528-44-6 (unlabeled)
Molecular Weight:
499.48
Molecular Formula:
C23H25D3O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Mycophenolic Acid-d3 β-D-Glucuronide is a deuterated derivative specifically designed for use as an internal standard in analytical chemistry, particularly in the context of mass spectrometry and liquid chromatography. Its structure incorporates deuterium atoms, replacing the hydrogen atoms, which significantly enhances its stability and makes it an ideal reference compound for quantitative analysis. This derivative is extensively utilized in the study of metabolic pathways and the elucidation of pharmacokinetic profiles of mycophenolic acid in various research applications, excluding any clinical or therapeutic contexts. Its role in research is pivotal for understanding the dynamics of mycophenolic acid metabolism and for the accurate measurement of this compound in complex biological matrices, thereby contributing to the broader field of pharmacological and biochemical studies focused on elucidating the behavior of compounds within biological systems.


Mycophenolic Acid-d3 β-D-Glucuronide (CAS 31528-44-6 (unlabeled)) References

  1. Pharmacodynamics of immunosuppression by mycophenolic acid: inhibition of both lymphocyte proliferation and activation correlates with pharmacokinetics.  |  Gummert, JF., et al. 1999. J Pharmacol Exp Ther. 291: 1100-12. PMID: 10565830
  2. Effect of pterostilbene on in vitro drug metabolizing enzyme activity.  |  Albassam, AA. and Frye, RF. 2019. Saudi Pharm J. 27: 406-412. PMID: 30976185
  3. Noncompartmental pharmacokinetics of three intravenous mycophenolate mofetil concentrations in healthy Standardbred mares.  |  Burroughs, DL., et al. 2022. Vet Dermatol.. PMID: 35929548
  4. Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.  |  Senda, M., et al. 1995. Transplantation. 60: 1143-8. PMID: 7482723
  5. Conformational changes and stabilization of inosine 5'-monophosphate dehydrogenase associated with ligand binding and inhibition by mycophenolic acid.  |  Nimmesgern, E., et al. 1996. J Biol Chem. 271: 19421-7. PMID: 8702630

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Mycophenolic Acid-d3 β-D-Glucuronide, 1 mg

sc-218897
1 mg
$816.00